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Klin Monbl Augenheilkd 2022; 239(04): 390-392
DOI: 10.1055/a-1785-4320
Der interessante Fall

Recurrent Corneal and Conjunctival Dysplasia in an Immunocompromised Patient – The Interesting Case

Rezidivierende Hornhaut- und Bindehautdysplasie bei einem immungeschwächten Patienten – der interessante Fall
Yasmine Derradji
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
,
Peter Meyer
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
,
Zisis Gatzioufas
Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
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Background

Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia, which is a precancerous lesion and part of the spectrum of diseases called ocular surface squamous neoplasia (OSSN). The lesion usually develops at the limbal region of the interpalpebral conjunctiva. Main risk factors include ultraviolet light exposure, human papillomavirus (HPV) infection, and immunosuppression (HIV/AIDS). Surgical excision, usually with adjunctive cryotherapy, has been the traditional therapy for OSSN [1]. Because of a high recurrence rate after surgical excision [2], topical chemotherapy including mitomycin-C (MMC), 5-fluorouracil (5-FU), and interferon (IFN) has been used extensively [3], [4], [5]. Here, we report a case of recurrent conjunctival and corneal intraepithelial neoplasia.



Publication History

Received: 14 September 2021

Accepted: 27 February 2022

Article published online:
26 April 2022

© 2022. Thieme. All rights reserved.

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