Design, Synthesis, and Screening of Pyridothieno[3,2-b]indole and Pyridothieno[3,2-c]cinnoline Derivatives as Potential Biologically Active Molecules

Abstract

New pyridothieno[3,2-b]indole and pyridothieno[3,2-c]cinnoline derivatives are designed and prepared from the corresponding 3-amino-2-arylthieno[2,3-b]pyridines. By a molecular docking method novel potential inhibitors of DNA gyrase B are identified among the thieno[2,3-b]pyridine derivatives. In addition, some of the prepared pyridothienoindoles exhibit in vivo antidote activity against the herbicide 2,4-D.

Key words

pyridothienoindoles - azide - thermolysis - antidote activity - DNA gyrase inhibitors - molecular docking - ADMET

Publication History

Received: 31 December 2021

Accepted after revision: 02 March 2022

Accepted Manuscript online:
02 March 2022

Article published online:
19 May 2022

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