Design, Synthesis, and Screening of Pyridothieno[3,2-b]indole and Pyridothieno[3,2-c]cinnoline Derivatives as Potential Biologically Active Molecules

Vladimir K. Vasilin; Eugeniya A. Kanishcheva; Tatyana A. Stroganova; Irina G. Dmitrieva; Viktor V. Taranenko; Roman S. Tumskiy; Anastasiia V. Tumskaia; Nikolay A. Aksenov; Gennady D. Krapivin

doi:10.1055/a-1785-7191

Synthesis, Inhaltsverzeichnis

Synthesis 2022; 54(14): 3249-3261
DOI: 10.1055/a-1785-7191

paper

Design, Synthesis, and Screening of Pyridothieno[3,2-b]indole and Pyridothieno[3,2-c]cinnoline Derivatives as Potential Biologically Active Molecules

Vladimir K. Vasilin

^aDepartment of Bioorganic Chemistry and Technical Microbiology, Kuban State Technological University, 2, Moskovskaya st, Krasnodar 350072, Russian Federation

,

Eugeniya A. Kanishcheva

^bResearch Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University, 2, Moskovskaya st, Krasnodar 350072, Russian Federation

,

Tatyana A. Stroganova∗

^aDepartment of Bioorganic Chemistry and Technical Microbiology, Kuban State Technological University, 2, Moskovskaya st, Krasnodar 350072, Russian Federation

,

Irina G. Dmitrieva

^cFSBSI All-Russian Research Institute of Biological Plant Protection, Krasnodar-39, 350039, Russian Federation

,

Viktor V. Taranenko

^dDepartment of Organic Chemistry, Kuban State Agrarian University, Kalinina st. 13, Krasnodar 350044, Russian Federation

,

Roman S. Tumskiy

^eInstitute of Biochemistry and Physiology of Plants and Microorganisms (IBPPM RAS), Russian Academy of Sciences, 13 Prospekt Entuziastov, Saratov 410049, Russian Federation

,

Anastasiia V. Tumskaia

^fChemistry Institute, Saratov State University, 83 Astrakhanskaya st., Saratov 410012, Russian Federation

,

Nikolay A. Aksenov

^gDepartment of Organic Chemistry, North Caucasus Federal University, Pushkina st., 1, Stavropol 355009, Russian Federation

,

Gennady D. Krapivin

^bResearch Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University, 2, Moskovskaya st, Krasnodar 350072, Russian Federation

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Abstract

Alle Artikel dieser Rubrik

Abstract

New pyridothieno[3,2-b]indole and pyridothieno[3,2-c]cinnoline derivatives are designed and prepared from the corresponding 3-amino-2-arylthieno[2,3-b]pyridines. By a molecular docking method novel potential inhibitors of DNA gyrase B are identified among the thieno[2,3-b]pyridine derivatives. In addition, some of the prepared pyridothienoindoles exhibit in vivo antidote activity against the herbicide 2,4-D.

Key words

pyridothienoindoles - azide - thermolysis - antidote activity - DNA gyrase inhibitors - molecular docking - ADMET

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