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Planta Med 2022; 88(09/10): 729-734
DOI: 10.1055/a-1786-8072
Biological and Pharmacological Activity
Original Papers

New Terpenoids from the Corticioid Fungus Punctularia atropurpurascens and their Antimycobacterial Evaluation[ # ]

Daniel Acero
1   Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
,
Firoz Shah Tuglak Khan
2   Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA
,
Abraham J. Medina-Ortiz
3   Departamento de Laboratorios, Colegio de Ciencias y Humanidades Plantel Sur, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
,
Isabel Rivero-Cruz
1   Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
,
Huzefa A. Raja
2   Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA
,
Laura Flores-Bocanegra
2   Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA
,
Carlos A. Fajardo-Hernández
1   Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
,
Baojie Wan
4   Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA
,
Scott G. Franzblau
4   Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA
,
Shabnam Hematian
2   Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA
,
Mario Figueroa 
1   Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
› Author AffiliationsSupported by: Facultad de Química, Universidad Nacional Autónoma de México PAIP 5000-9145
Supported by: Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México PAPIIT IN222220
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Abstract

Chemical investigation of Punctularia atropurpurascens strain HM1 (Punctulariaceae), a corticioid isolated from a decorticated piece of Quercus bark collected in Bosque de Tlalpan, Mexico City, led to the isolation of a new drimane, 1-α-hydroxy-isodrimenine (1) and a new tetrahydroxy kauranol, 16-hydroxy-phlebia-nor-kauranol (2), together with the known N-phenylacetamide (3). Structures of all compounds were elucidated by spectroscopic and spectrometric methods, and the absolute configuration of 1 and 2 was confirmed via single-crystal X-ray crystallography. The isolated compounds showed modest antimycobacterial activity.

Key words

Punctularia atropurpurascens - corticioid - drimane - nor-kaurane - antitubercular activity - Punctulariaceae

# Dedicated to Professor Dr. A. Douglas Kinghorn on the occasion of his 75th birthday.


Supporting Information

    Molecular phylogenetic analysis of the fungal strain, MS and NMR data and UPLC profiles of 1–3, and X-ray crystallographic data of 1 and 2, are available as Supporting Information.

  • Supporting Information


Publication History

Received: 15 December 2021

Accepted after revision: 22 February 2022

Article published online:
30 March 2022

© 2022. Thieme. All rights reserved.

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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