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Synthesis 2022; 54(22): 4963-4970
DOI: 10.1055/a-1786-9881
DOI: 10.1055/a-1786-9881
special topic
Aryne Chemistry in Synthesis
Formal Syntheses of Dictyodendrins B, C, and E by a Multi-Substituted Indole Synthesis
This work was supported by JSPS KAKENHI Grant Number JP19H02726 (to J.Y.). This work was partly supported by JST ERATO Grant Number JPMJER1901.
Abstract
The dictyodendrins are a family of marine alkaloids, which possess a highly substituted pyrrolo[2,3-c]carbazole core. This core structure can be regarded as a multi-substituted indole and aniline moiety. To achieve a concise synthesis of dictyodendrins, we planned to capitalize on our previously developed multi-substituted indole synthesis. By using this method along with two C–H functionalizations, formal syntheses of dictyodendrins B, C, and E were achieved.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1786-9881.
- Supporting Information
- CIF File
Publication History
Received: 12 February 2022
Accepted after revision: 03 March 2022
Accepted Manuscript online:
03 March 2022
Article published online:
10 October 2022
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