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Synthesis 2022; 54(20): 4472-4480
DOI: 10.1055/a-1790-2282
DOI: 10.1055/a-1790-2282
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Facile Access to α-Substituted β-Thio Enals from 1,2,3-Triazines and Thiols
This work was supported by NSFC (Grant 21772019) and the Venture and Innovation Support Program for Chongqing Overseas Returnees (cx2019007 & cx2020047).

Abstract
Herein, a chemoselective cascade addition reaction is reported, which starts from 1,2,3-triazines and thiols to access several different α-substituted β-thio enals and their derivatives in a green and efficient synthesis. In terms of applications, readily available substrates, diversity of products, and mild reaction system make this strategy highly attractive.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1790-2282.
- Supporting Information
Publication History
Received: 11 February 2022
Accepted after revision: 07 March 2022
Accepted Manuscript online:
07 March 2022
Article published online:
04 May 2022
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