Synthesis 2022; 54(20): 4472-4480
DOI: 10.1055/a-1790-2282
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Facile Access to α-Substituted β-Thio Enals from 1,2,3-Triazines and Thiols

Han Luo
,
Qixing Lu
,
Mingchuan Xu
,
Mingxi Gu
,
Baosheng Li
This work was supported by NSFC (Grant 21772019) and the Venture and Innovation Support Program for Chongqing Overseas Returnees (cx2019007 & cx2020047).


Abstract

Herein, a chemoselective cascade addition reaction is reported, which starts from 1,2,3-triazines and thiols to access several different α-substituted β-thio enals and their derivatives in a green and efficient synthesis. In terms of applications, readily available substrates, diversity of products, and mild reaction system make this strategy highly attractive.

Supporting Information



Publication History

Received: 11 February 2022

Accepted after revision: 07 March 2022

Accepted Manuscript online:
07 March 2022

Article published online:
04 May 2022

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