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Synthesis 2022; 54(21): 4784-4794
DOI: 10.1055/a-1802-6793
DOI: 10.1055/a-1802-6793
special topic
Asymmetric C–H Functionalization
Synthesis of P- and S-Stereogenic Compounds via Enantioselective C–H Functionalization
Financial support from the National Natural Science Foundation of China (NSFC) (21925109 and 21801223), the Open Research Fund of the School of Chemistry and Chemical Engineering of Henan Normal University and the Center of Chemistry for Frontier Technologies of Zhejiang University is gratefully acknowledged.
Abstract
Transition metal-catalyzed enantioselective C–H functionalization has emerged as an efficient and powerful strategy to access various chiral molecules. Recently, this strategy has also provided a complementary pathway to the construction of P- and S-stereogenic compounds. In this short review, we summarize the development and applications of various catalytic systems: Pd(II)/mono-N-protected amino acids (MPAA), Pd(0)/trivalent phosphorus chiral ligands, chiral cyclopentadienyl-ligated metal catalysts [CpxM(III)] (M = Rh, Ir), half-sandwich d6 Ir(III) and Ru(II) with a chiral carboxylic acid (CCA) ligand, Ir(I)/chiral bidentate boryl ligand, and Ir(I)/chiral cation, for accessing these chiral compounds via enantioselective C–H functionalization.
1 Introduction
2 Pd(II)/Mono-N-protected Amino Acids
3 Pd(0)/Trivalent Phosphorus Chiral Ligands
4 Chiral Cyclopentadienyl-Ligated Metal Catalysts [CpxM(III)] (M = Rh, Ir)
5 Half-sandwich d6 Ir(III) and Ru(II) with a Chiral Carboxylic Acid (CCA) Ligand
6 Ir(I)/Chiral Bidentate Boryl Ligand
7 Ir(I)/Chiral Cation
8 Conclusion and Outlook
Key words
enantioselectivity - C–H functionalization - P- and S-stereogenic compounds - chiral ligands - transition metalsPublication History
Received: 22 February 2022
Accepted after revision: 18 March 2022
Accepted Manuscript online:
18 March 2022
Article published online:
12 May 2022
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For selected examples of P-stereogenic bioactive compounds, see:
For selective examples of S-stereogenic bioactive compounds, see:
For reviews on asymmetric syntheses of P-stereogenic compounds, see:
For reviews on asymmetric syntheses of S-stereogenic compounds, see: