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Synthesis 2022; 54(14): 3262-3270
DOI: 10.1055/a-1804-8859
DOI: 10.1055/a-1804-8859
paper
Radical Oxyazidation of Alkenes in Pure Water
This work was supported by the National Natural Science Foundation of China (NSFC) (22001251, 21871258, 21922112), the National Key Research and Development Program of China (2017YFA0700103), and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB20000000).
Abstract
Compared to universal radical difunctionalizations of alkenes that are performed with organic solvents, such reactions with water as the sole solvent are rarely reported. Concerning the global consensus on environmental issues, we have developed herein a method for the radical oxyazidation of alkenes in pure water. This reaction allows the construction of C–N and C–O bonds in a one-pot process. Styrenes, 1,3-dienes, and unactivated alkenes react smoothly under mild and environmentally benign conditions to afford a wide scope of functionalized azides in excellent yields and selectivities.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1804-8859.
- Supporting Information
Publication History
Received: 09 February 2022
Accepted after revision: 22 March 2022
Accepted Manuscript online:
22 March 2022
Article published online:
25 April 2022
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