Update Breast Cancer 2022 Part 1 – Early Stage Breast Cancer

Manfred Welslau; Volkmar Müller; Diana Lüftner; Florian Schütz; Elmar Stickeler; Peter A. Fasching; Wolfgang Janni; Christoph Thomssen; Isabell Witzel; Tanja N. Fehm; Erik Belleville; Simon Bader; Katharina Seitz; Michael Untch; Marc Thill; Hans Tesch; Nina Ditsch; Michael P. Lux; Bahriye Aktas; Maggie Banys-Paluchowski; Andreas Schneeweiss; Nadia Harbeck; Rachel Würstlein; Andreas D. Hartkopf; Achim Wöckel; Barbara Seliger; Chiara Massa; Hans-Christian Kolberg

doi:10.1055/a-1811-6106

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(06): 580-589
DOI: 10.1055/a-1811-6106

GebFra Science

Review/Übersicht

Update Breast Cancer 2022 Part 1 – Early Stage Breast Cancer

Article in several languages: English | deutsch

Manfred Welslau

¹Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Volkmar Müller

²Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Diana Lüftner

³Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany

,

Florian Schütz

⁴Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Elmar Stickeler

⁵Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

,

Peter A. Fasching

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁷Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Christoph Thomssen

⁸Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Isabell Witzel

²Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Tanja N. Fehm

⁹Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Erik Belleville

¹⁰ClinSol GmbH & Co KG, Würzburg, Germany

,

Simon Bader

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Katharina Seitz

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Michael Untch

¹¹Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Marc Thill

¹²Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main

,

Hans Tesch

¹³Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

,

Nina Ditsch

¹⁴Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Michael P. Lux

¹⁵Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Germany

,

Bahriye Aktas

¹⁶Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Leipzig, Leipzig, Germany

,

Maggie Banys-Paluchowski

¹⁷Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

,

Andreas Schneeweiss

¹⁸National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

,

Nadia Harbeck

¹⁹Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Rachel Würstlein

¹⁹Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Andreas D. Hartkopf

⁷Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Achim Wöckel

²⁰Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Barbara Seliger

²¹Martin-Luther-Universitat Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany

,

Chiara Massa

²¹Martin-Luther-Universitat Halle-Wittenberg, Institute of Medical Immunology, Halle (Saale), Germany

,

Hans-Christian Kolberg

²²Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

› Author Affiliations

Abstract

Evidence relating to the treatment of breast cancer patients with early-stage disease has increased significantly in the past year. Abemaciclib, olaparib, and pembrolizumab are new drugs with good efficacy in the relevant patient groups. However, some questions remain unanswered. In particular, it remains unclear which premenopausal patients with hormone receptor-positive breast cancer should be spared unnecessary treatment. The question of the degree to which chemotherapy exerts a direct cytotoxic effect on the tumor or reduces ovarian function through chemotherapy could be of key importance. This group of patients could potentially be spared chemotherapy. New, previously experimental biomarker analysis methods, such as spatial analysis of gene expression (spatial transcriptomics) are gradually finding their way into large randomized phase III trials, such as the NeoTRIP trial. This in turn leads to a better understanding of the predictive factors of new therapies, for example immunotherapy. This review summarizes the scientific innovations from recent congresses such as the San Antonio Breast Cancer Symposium 2021 but also from recent publications.

Key words

BRCA (breast cancer antigen) - breast cancer - estrogen receptor - oral therapy

Full Text

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