Assembly of the Hydroxycinnoline Core via Hydrazide-Assisted Rh(III)-Catalyzed C–H Functionalization and Annulation

Abstract

The structural modification of phthalazinones and indazolones has emerged as a pivotal topic in catalytic C–H functionalization events. Herein we report the hydrazide-assisted rhodium(III)-catalyzed cross-coupling reactions of N-arylphthalazinones and N-arylindazolones with vinylene carbonate. This method provides direct access to tetracyclic hydroxycinnolines. Complete site-selectivity and functional group compatibility were observed.

Key words

C–H functionalization - cinnolines - indazolones - phthalazinones - rhodium - vinylene carbonate

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