Pentosan Polysulfate—A “Better Heparin” as Potential Medication for the Treatment of SARS-CoV-2 Infections?

Thromb Haemost 2022; 122(06): 870
DOI: 10.1055/a-1815-2142

Invited T&H Inisghts

Gerd Bendas

¹Department of Pharmacy, University of Bonn, Bonn, Germany

References
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2 van Haren FMP, Page C, Laffey JG. et al. Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence. Crit Care 2020; 24 (01) 454
3 Bertini S, Alekseeva A, Elli S. et al. Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding. Thromb Haemost 2022;122(06):
4 Zhang F, He P, Rodrigues AL. et al. Potential anti-SARS-CoV-2 activity of pentosan polysulfate and mucopolysaccharide polysulfate. Pharmaceuticals (Basel) 2022; 15 (02) 258