Physiological Functions of FBW7 in Metabolism

Abstract

FBW7 is the recognition subunit of the SCF (Skp1-Cullin1-F-box proteins) E3 ubiquitin ligase complex, and it determines the specificity of the SCF substrate. SCFFBW7 is a recognized tumor suppressor because of its ability to degrade many proto-oncogenic substrates. Recent studies have shown that FBW7 plays a key role in metabolism by targeting the degradation of critical regulators involved in cellular metabolism in a ubiquitin-dependent manner. Here, we review recent studies, which highlight the important role of FBW7 in metabolism.

Keywords

FBW7 - glucose metabolism -  metabolic syndrome - lipid metabolism - obesity

Publication History

Received: 14 October 2021

Accepted after revision: 04 April 2022

Article published online:
09 May 2022

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