Recent Advances in the Total Synthesis of Cephalotane-Type Norditerpenoids from Cephalotaxus sinensis

Abstract

Cephalotaxus diterpenoids are well known for their unique structures and biological activities. Cephanolides, as new cephalotane-type norditerpenoids isolated from Cephalotaxus sinensis, have attracted considerable attention from the synthetic community. The present Short Review summarizes strategic approaches toward the total synthesis of cephanolides from 2018 to 2021.

1 Introduction

2 Synthetic Approaches toward Cephalotane-Type Norditerpenoids

2.1 First Total Synthesis of Cephanolides B and C by Zhao (2018)

2.2 Total Synthesis of Cephanolides A–D by Sarpong (2021)

2.3 Total Synthesis of Cephanolide B by Yang (2021)

2.4 Asymmetric Total Synthesis of Cephanolide A by Gao (2020)

2.5 Asymmetric Total Synthesis of Cephanolide B by Gao (2021)

2.6 Asymmetric Total Synthesis of Cephanolides A and B by Cai (2021)

3 Conclusion and Perspectives

Key words

cephalotane-type - norditerpenoids - total synthesis - cephanolides - Cephalotaxus

Publication History

Received: 03 March 2022

Accepted after revision: 19 April 2022

Accepted Manuscript online:
19 April 2022

Article published online:
30 May 2022

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