Endokrine Disruptoren

Was ist neu?

Definition Eine einheitliche Definition endokriner Disruptoren gibt es noch nicht. Inzwischen wurden jedoch Schlüsselcharakteristika definiert, welche die Einordnung einer Substanz als endokrinen Disruptor vereinfachen sollen.

Bisherige Forschungsschwerpunkte Der Einfluss endokriner Disruptoren auf den menschlichen Organismus wurde bisher wenig untersucht. Die Schwerpunkte der bisherigen Forschung liegen auf Stoffwechsel-Erkrankungen und Reproduktionsmedizin.

Aktuelle Forschungsbemühungen und Ausblick Die bisherigen Erkenntnisse zu endokrinen Disruptoren beruhen auf epidemiologischen Beobachtungen und Expositionsstudien in Zellkultur und Tierexperimenten. Auch Ökologie und Ökonomie werden durch endokrine Disruptoren beeinflusst. Daher sind globale Bemühungen notwendig, um irreversible Schäden aufzuhalten.

Abstract

Endocrine disrupting chemicals (EDCs) are universally occurring substances with the potential to interrupt the hormonal system, although the definition of EDCs is not yet standardized. Similar to hormones, EDCs are potentially able to act at very low concentrations, which might be considered save from a toxicological viewpoint. Research over the past years showed that EDCs, even in low doses, might have a relevant impact on human health and the environment as well.

The increase of disease burden and disability induced by EDCs causes substantial costs for society. Thus, besides the implications on personal and global health, EDCs affect the economy as well and pose a universal threat to society and environment. Many of the potentially hazardous substances are still inadequately examined and regulated.

In this review, we give a brief summary on the previous efforts to classify EDCs and provide a short summary of the current knowledge

Schlüsselwörter

EDC - Disruptor - Adipositas - Diabetes - Reproduktionsmedizin - Schilddrüse

Key words

EDC - disruptor - obesity - diabetes - reproductive health - thyroid gland

Publication History

Article published online:
01 November 2022

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