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DOI: 10.1055/a-1840-5483
α-C–H Photoalkylation of a Glucose Derivative in Continuous Flow
This work is supported by the Carbohydrate Competence Center’s (CCC) ‘CarboBased’ program.
Abstract
Site-selective photoalkylation is a powerful strategy to extend the carbon framework of carbohydrates, otherwise often attainable only through laborious syntheses. This work describes the adaptation and upscaling of the photoalkylation of a glucose derivative as a continuous flow process. The reported iridium catalyst is replaced by an organic sensitizer and the reaction has been carried out on 40-gram scale.
Key words
C–H functionalization - photoredox catalysis - carbohydrates - flow chemistry - hydrogen atom transfer - radicalsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1840-5483.
- Supporting Information
Publication History
Received: 20 March 2022
Accepted after revision: 28 April 2022
Accepted Manuscript online:
02 May 2022
Article published online:
14 June 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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