Subscribe to RSS
DOI: 10.1055/a-1849-8953
Wenn COVID nicht aufhört: Post-COVID-Verläufe mit Fatigue und Belastungsintoleranz
When COVID does not heal: post-COVID courses with fatigue and exercise intoleranceHinter „Post-COVID“ verbergen sich pathobiologisch unterschiedliche Entitäten, von Schädigungen bestimmter Organe bis hin zu neu auftretenden Autoimmun-Erkrankungen. In diesem Beitrag wird es vor allem um die Langzeitverläufe mit den Leitsymptomen Fatigue und Belastungsintoleranz gehen. Sie sind auch von anderen Infektionskrankheiten bekannt und umfassen als schwerwiegendste Entität die Systemerkrankung Myalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom.
Abstract
Post-COVID-Syndrome consists of several pathobiologically different entities, ranging from damage to specific organs to new onset autoimmune diseases. This article focuses on post-COVID courses with the leading symptoms of fatigue and exercise intolerance. This category is also known from other infectious diseases and includes myalgic encephalomyelitis/chronic fatigue syndrome.
Schlüsselwörter
Post-COVID-Syndrom - Long-COVID - chronisches Fatigue-Syndrom - posturales Tachykardiesyndrom - BelastungsintoleranzKey words
post-COVID syndrome - long-COVID - chronic fatigue syndrome - postural tachycardia syndrome - exercise intolerancePublication History
Article published online:
04 October 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 AWMF. S1-Leitlinie Long/Post-COVID. AWMF-Register-Nr. 020-027; 17.08.2022. Im Internet (Stand: 19.08.2022): https://www.awmf.org/leitlinien/detail/ll/020-027.html
- 2 Yong SJ, Liu S. Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies. Rev Med Virol 2022; 32: e2315
- 3 Kedor C, Freitag H, Meyer-Arndt L. A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity. Nat Commun 2022; 13 (01) 5104
- 4 Couzin-Frankel J, Vogel G. In rare cases, coronavirus vaccines may cause Long Covid-like symptoms. Im Internet (Stand: 18.08.2022): https://www.science.org/content/article/rare-cases-coronavirus-vaccines-may-cause-long-covid-symptoms
- 5 Davis HE, Assaf GS, McCorkell L. et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine 2021; 38: 101019
- 6 Proal AD, VanElzakker MB. Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms. Front Microbiol 2021; 12: 698169
- 7 Krishna BA, Lim EY, Mactavous L. et al. Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID. EBioMedicine 2022; 81: 104129
- 8 Sudre CH, Murray B, Varsavsky T. et al. Attributes and predictors of long COVID. Nat Med 2021; 27: 626-631
- 9 Chen C, Haupert SR, Zimmermann L. et al. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. J Infect Dis 2022; 136
- 10 Han Q, Zheng B, Daines L. et al. Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. Pathogens 2022; 11: 269
- 11 Buchberger B, Zwierlein R, Rohde V. Post-Corona-Fatigue – das bekannte Bild in neuem Gewand?. Onkologe (Berl.) 2022; 28: 340-346
- 12 Cerqueira É, Marinho DA, Neiva HP. et al. Inflammatory Effects of High and Moderate Intensity Exercise – A Systematic Review. Front Physiol 2020; 10: 1550
- 13 Renz-Polster H, Tremblay ME, Bienzle D. et al. The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure. Front Cell Neurosci 2022; 16: 888232
- 14 Wirth K, Scheibenbogen C. A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against β2-adrenergic receptors. Autoimmun Rev 2020; 19: 102527
- 15 Chadda KR, Blakey EE, Huang CLH. et al. Long COVID-19 and Postural Orthostatic Tachycardia Syndrome – Is Dysautonomia to Be Blamed?. Front Cardiovasc Med 2022; 9: 860198
- 16 Klingenheben T. Autonome Dysfunktion und orthostatische Intoleranz. Internist 2002; 43: 1055-1064
- 17 Wise S, Ross A, Brown A. et al. An assessment of fatigue in patients with postural orthostatic tachycardia syndrome. J Health Psychol 2017; 22: 733-742
- 18 Vernino S, Bourne KM, Stiles LE. et al. Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting – Part 1. J Auton Nerv Syst 2021; 235: 102828
- 19 Joseph A, Wanono R, Flamant M. et al. Orthostatic hypotension: A review. Nephrol Ther 2017; 13 (Suppl. 01) S55-S67
- 20 Choutka J, Jansari V, Hornig M. et al. Unexplained post-acute infection syndromes. Nat Med 2022; 28: 911-923
- 21 Lam MHB, Wing YK, Yu MWM. et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med 2009; 169: 2142-2147
- 22 Renz-Polster H, Scheibenbogen C. Post-COVID-Syndrom mit Fatigue und Belastungsintoleranz: Myalgische Enzephalomyelitis bzw. Chronisches Fatigue-Syndrom. Inn Med (Heidelb) 2022; 63: 830-839
- 23 Jason LA, Mirin AA. Updating the National Academy of Medicine ME/CFS prevalence and economic impact figures to account for population growth and inflation. Fatigue Biomed Health Behav 2021; 9: 9-13
- 24 Tokumasu K, Honda H, Sunada N. et al. Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID. Medicina (Kaunas) 2022; 58: 850
- 25 Sukocheva OA, Maksoud R, Beeraka NM. et al. Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome. J Adv Res 2021;
- 26 Pendergrast T, Brown A, Sunnquist M. et al. Housebound versus nonhousebound patients with myalgic encephalomyelitis and chronic fatigue syndrome. Chronic Illn 2016; 12: 292-307
- 27 Nacul L, O’Boyle S, Palla L. et al. How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS. Front Neurol 2020; 11: 826
- 28 Carruthers BM, Jain AK, De Meirleir KL. et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Chronic Fatigue Syndr 2003; 11: 7-115
- 29 van Campen CLMC, Verheugt FWA, Rowe PC. et al. Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography. Clin Neurophysiol Pract 2020; 5: 50-58
- 30 Melamed KH, Santos M, Oliveira RKF. et al. Unexplained exertional intolerance associated with impaired systemic oxygen extraction. Eur J Appl Physiol 2019; 119: 2375-2389
- 31 Joseph P, Arevalo C, Oliveira RKF. et al. Insights From Invasive Cardiopulmonary Exercise Testing of Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Chest 2021; 160: 642-651
- 32 Singh I, Joseph P, Heerdt PM. et al. Persistent Exertional Intolerance after COVID-19: Insights from Invasive Cardiopulmonary Exercise Testing. Chest 2021; 161: 54-63
- 33 van Campen CLMC, Rowe PC, Visser FC. Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Medicina (Kaunas) 2022; 58: 28
- 34 Wallukat G, Hohberger B, Wenzel K. et al. Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms. J Transl Autoimmun 2021; 4: 100100
- 35 Loebel M, Grabowski P, Heidecke H. et al. Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome. Brain Behav Immun 2016; 52: 32-39