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CC BY-NC-ND 4.0 · Z Geburtshilfe Neonatol 2022; 226(06): 399-404
DOI: 10.1055/a-1850-2475
Original Article

Analysis of Factors Related to Neonatal Infection and Monitoring of Bacterial Drug Resistance

Jingwen Xu
1   Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
,
Yanhong Zhang
1   Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
,
Hui Ma
1   Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
,
Renyan Zhang
1   Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
,
Jie Wu
1   Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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Abstract

Objective To study the factors related to neonatal infection, as well as bacterial distribution and drug resistance in neonatal infections, in an obstetrics and gynecology hospital in Shanghai.

Methods The bacterial culture and drug resistance monitoring results from neonates treated at the hospital from January 2020 to June 2021 were analyzed and compared with the data for children and newborns from the national bacterial resistance surveillance report.

Results Among the 209 bacterial strains isolated from infected neonates, 90 were gram-positive, including the four most common isolates: coagulase-negative Staphylococcus, Staphylococcus aureus, Enterococcus, and Streptococcus agalactiae. The remaining 119 strains were gram-negative and included Klebsiella pneumoniae, Acinetobacter baumannii, and Enterobacter aerogenes. The drug sensitivity results showed that the methicillin-resistant Staphylococcus aureus isolates were sensitive to linezolid, vancomycin, rifampicin, levofloxacin, and gentamicin. All Klebsiella pneumoniaisolates were sensitive to amikacin, ertapenem, imipenem, and gentamicin. These two strains were resistant to other antibiotics to varying degrees.

Conclusions Understanding the distribution and drug resistance of bacterial pathogens is vital for guiding the rational selection of antibiotics and reducing neonatal mortality and nosocomial infections.

Key words

newborn - Bacterial distribution - Bacterial resistance - National bacterial resistance monitoring network


Publikationsverlauf

Eingereicht: 23. April 2022

Angenommen nach Revision: 27. April 2022

Artikel online veröffentlicht:
04. Juli 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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