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Synthesis 2022; 54(22): 4932-4962
DOI: 10.1055/a-1863-8622
DOI: 10.1055/a-1863-8622
special topic
Aryne Chemistry in Synthesis
Aryne Annulations for the Synthesis of Carbocycles and Heterocycles: An Updated Review
We thank Council of Scientific and Industrial Research (CSIR), New Delhi, India for financial support (Project no. MLP-1015). M.S. thanks the Department of Science and Technology, Science and Engineering Research Board (DST-SERB) for financial assistance in the form of NPDF (PDF/2019/000564). H.H. thanks the Department of Science and Technology, New Delhi, for DST-Inspire Fellowship Grants.
Abstract
Carbocycles and heterocycles are highly relevant structural moieties that have found countless applications in interdisciplinary areas. In this regard, the interesting chemistry of arynes has been embraced by researchers for the synthesis of structurally different polycyclic systems, i.e. carbocycles and heterocycles. In this review, we intended to provide a comprehensive overview on the annulative approach considering Kobayashi’s aryne intermediate as the key reactive species with diverse nucleophilic and electrophilic partners. The review highlights the different aryne annulation reactions adopted for the synthesis of carbocycles and heterocycles (covering articles mainly from around 2010), showcasing their viability towards broad range of substrates bearing diverse functionalities.
1 Introduction
2 Synthesis of Carbocycles
3 Synthesis of Heterocycles
4 Conclusions
Publication History
Received: 23 March 2022
Accepted after revision: 30 May 2022
Accepted Manuscript online:
30 May 2022
Article published online:
12 July 2022
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