Aryne Annulations for the Synthesis of Carbocycles and Heterocycles: An Updated Review

Manashi Sarmah; Hemanta Hazarika; Pranjal Gogoi

doi:10.1055/a-1863-8622

Synthesis, Table of Contents

Synthesis 2022; 54(22): 4932-4962
DOI: 10.1055/a-1863-8622

special topic

Aryne Chemistry in Synthesis

Aryne Annulations for the Synthesis of Carbocycles and Heterocycles: An Updated Review

Manashi Sarmah

^aApplied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Assam, Jorhat 785006, India

,

Hemanta Hazarika

^aApplied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Assam, Jorhat 785006, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

,

Pranjal Gogoi∗

^aApplied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Assam, Jorhat 785006, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

› Author Affiliations

Abstract

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Abstract

Carbocycles and heterocycles are highly relevant structural moieties that have found countless applications in interdisciplinary areas. In this regard, the interesting chemistry of arynes has been embraced by researchers for the synthesis of structurally different polycyclic systems, i.e. carbocycles and heterocycles. In this review, we intended to provide a comprehensive overview on the annulative approach considering Kobayashi’s aryne intermediate as the key reactive species with diverse nucleophilic and electrophilic partners. The review highlights the different aryne annulation reactions adopted for the synthesis of carbocycles and heterocycles (covering articles mainly from around 2010), showcasing their viability towards broad range of substrates bearing diverse functionalities.

1 Introduction

2 Synthesis of Carbocycles

3 Synthesis of Heterocycles

4 Conclusions

Key words

Kobayashi’s aryne - annulation - carbocycle - heterocycle - polyaromatic hydrocarbons

Full Text

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