Metal- and Additive-Free Intermolecular Aziridination of Olefins Using N-Boc-O-tosylhydroxylamine

Abstract

A metal and additive-free stereospecific direct N-H and N-Me aziridination of inactivated olefins is disclosed using N-Boc-O-tosyl­hydroxylamine (TsONHBoc) as an aminating agent in hexafluoroisopropanol (HFIP). The use of TsONHBoc, which generates the free aminating agent in situ under the reaction conditions, has several inherent advantages over other similar agents, such as low cost, easy access, and stability (non-explosiveness) during storage over a longer time.

Key words

aziridination - TsONHBoc - metal and additives free - stereospecific­ - regioselective

Publikationsverlauf

Eingereicht: 20. Mai 2022

Angenommen nach Revision: 20. Juni 2022

Accepted Manuscript online:
20. Juni 2022

Artikel online veröffentlicht:
01. August 2022

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