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DOI: 10.1055/a-1892-9671
Synthetic Tools that Enable Synthesis and Understanding of Bioactive Macrocycles
The Natural Science and Engineering Research Council of Canada is gratefully acknowledged for financial support of this work.
In memory of Eric Marsault
Abstract
This article aims to summarizing the evolution of my lab’s research efforts in making and understanding peptide macrocycles. What started as a curiosity-driven investigation of amphoteric structures in multicomponent reactions, has turned into a sustained exploration of complex macrocyclic peptides. As part of this journey, my students and I have introduced new tools that enable chemical synthesis and property-driven optimization of cyclic peptides. These contributions are expected to be relevant in the areas of drug discovery and biological probe design.
Publication History
Received: 22 June 2022
Accepted after revision: 06 July 2022
Accepted Manuscript online:
06 July 2022
Article published online:
12 August 2022
© 2022. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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