CC BY-NC-ND 4.0 · SynOpen 2022; 06(03): 179-194
DOI: 10.1055/a-1896-4168
review

Recent Applications on Dual-Catalysis for C–C and C–X Cross-Coupling Reactions

Dakoju Ravi Kishore
,
Chinnabattigalla Sreenivasulu
,
Anil Balajirao Dapkekar
,
We greatly acknowledge financial support from the Council of Scientific and Industrial Research [(CSIR), No. 02(0262)/16/EMR-II], and DST-SERB (Science and Engineering Research Board, Department of Science and Technology, Grant EMR/2017/005312), New Delhi. D. R. and C. B. S. thank the University Grants Commission (UGC) New Delhi for providing Fellowships. A.B.D. thanks the Ministry of Human Resource Development (MHRD), for a Research Fellowship.


Dedicated to Prof. Günter Helmchen on the occasion of his 81st birthday

Abstract

Coupling reactions stand amid the most significant reactions in synthetic organic chemistry. Of late, these coupling strategies are being viewed as a versatile synthetic tool for a wide range of organic transformations in many sectors of chemistry, ranging from indispensable synthetic scaffolds and natural products of biological significance to novel organic materials. Further, the use of dual-catalysis in accomplishing various interesting cross-coupling transformations is an emerging field in synthetic organic chemistry, owing to their high catalytic performance rather than the use of a single catalyst. In recent years, synthetic organic chemists have given considerable attention to hetero-dual catalysis; wherein these catalytic systems have been employed for the construction of versatile carbon–carbon [C(sp 3)–C(sp 3), C(sp 3)–C(sp 2), C(sp 2)–C(sp 2)] and carbon–heteroatom (C–N, C–O, C–P, C–S) bonds. Therefore, in this mini-review, we are emphasizing recently developed various cross-coupling reactions catalysed by transition-metal dual-catalysis (i.e., using palladium and copper catalysts, but omitting the reports on photoredox/metal catalysis).

1 Introduction

2 Cu/Pd-Catalysed Bond Formation

2.1 Pd/Cu-Catalysed C(sp 3)–C(sp 2) Bond Formation

2.2 Pd/Cu-Catalysed C(sp 2)–C(sp 2) Bond Formation

2.3 Pd/Cu-Catalysed C(sp)–C(sp 2) Bond Formation

2.4 Pd/Cu-Catalysed C(sp 3)–C(sp 3) Bond Formation

2.5 Pd/Cu-Catalysed C–X (X = B, N, P, S, Si) Bond Formation

3 Conclusion



Publication History

Received: 16 June 2022

Accepted after revision: 11 July 2022

Accepted Manuscript online:
11 July 2022

Article published online:
03 August 2022

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