Sarcoma of the Uterus. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/074, April 2021)

Dominik Denschlag; Sven Ackermann; Marco Johannes Battista; Wolfgang Cremer; Gerlinde Egerer; Matthias Fehr; Markus Follmann; Heidemarie Haase; Philipp Harter; Simone Hettmer; Lars-Christian Horn; Ingolf Juhasz-Boess; Karin Kast; Günter Köhler; Thomas Kröncke; Katja Lindel; Peter Mallmann; Regine Meyer-Steinacker; Alexander Mustea; Edgar Petru; Peter Reichardt; Dietmar Schmidt; Hans-Georg Strauss; Falk Thiel; Uwe Andreas Ulrich; Thomas Vogl; Dirk Vordermark; Markus Wallwiener; Paul Gass; Matthias W. Beckmann

doi:10.1055/a-1897-5124

Geburtshilfe und Frauenheilkunde, Table of Contents

Geburtshilfe Frauenheilkd 2022; 82(12): 1337-1367
DOI: 10.1055/a-1897-5124

GebFra Science

Guideline/Leitlinie

Sarcoma of the Uterus. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/074, April 2021)

Article in several languages: English | deutsch

Dominik Denschlag

¹Frauenklinik, Hochtaunuskliniken Bad Homburg, Bad Homburg, Germany

,

Sven Ackermann

²Frauenklinik, Klinikum Darmstadt, Darmstadt, Germany

,

Marco Johannes Battista

³Universitätsmedizin Mainz, Klinik und Poliklinik für Geburtshilfe und Frauengesundheit, Mainz, Germany

,

Wolfgang Cremer

⁴Berufsverband der Frauenärzte, Hamburg, Germany

,

Gerlinde Egerer

⁵Universitätsklinik Heidelberg, Heidelberg, Germany

,

Matthias Fehr

⁶Kantonsspital Frauenfeld, Frauenfeld, Switzerland

,

Markus Follmann

⁷Deutsche Krebsgesellschaft, Berlin, Germany

,

Heidemarie Haase

⁸Frauenselbsthilfe nach Krebs e. V., Erlangen, Germany

,

Philipp Harter

⁹Klinik für Gynäkologie und Gynäkologische Onkologie, Kliniken Essen Mitte, Essen, Germany

,

Simone Hettmer

¹⁰Universitätsklinik Freiburg, Freiburg, Germany

,

Lars-Christian Horn

¹¹Abteilung für Mamma-, Urogenital, und Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany

,

Ingolf Juhasz-Boess

¹²Frauenklinik, Universitätsklinikum Freiburg, Freiburg, Germany

,

Karin Kast

¹³Nationales Zentrum für Familiäre Tumorerkrankungen (NCFT), Universitätsklinikum Köln, Köln, Germany

,

Günter Köhler

¹⁴Deutsches klinisches Kompetenzzentrum für genitale Sarkome und Mischtumoren, Universitätsmedizin Greifswald, Greifswald, Germany

,

Thomas Kröncke

¹⁵Klinik für Radiologie, Klinikum Augsburg, Augsburg, Germany

,

Katja Lindel

¹⁶Klinik für Radioonkologie, Klinikum Karlsruhe, Karlsruhe, Germany

,

Peter Mallmann

¹⁷Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Köln, Köln, Germany

,

Regine Meyer-Steinacker

¹⁸Universitätsklinik Ulm, Ulm, Germany

,

Alexander Mustea

¹⁹Klinik für Gynäkologie und Gynäkologische Onkologie, Universitätsklinikum Bonn, Bonn, Germany

,

Edgar Petru

²⁰Univ. Klinik für Frauenheilkunde und Geburtshilfe der Medizinischen Universität Graz, Graz, Austria

,

Peter Reichardt

²¹Klinik für interdisziplinäre Onkologie, Helios Kliniken Berlin-Buch, Berlin, Germany

,

Dietmar Schmidt

²²MVZ für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany

,

Hans-Georg Strauss

²³Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Halle, Halle/Saale, Germany

,

Falk Thiel

²⁴Frauenklinik, Alb Fils Kliniken, Göppingen, Germany

,

Uwe Andreas Ulrich

²⁵Klinik für Gynäkologie und Geburtshilfe, Martin Luther Krankenhaus Berlin, Johannesstift Diakonie, Berlin, Germany

,

Thomas Vogl

²⁶Institut für diagnostische und interventionelle Radiologie, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany

,

Dirk Vordermark

²⁷Universitätsklinik und Poliklinik für Strahlentherapie, Universitätsklinikum Halle, Halle/Saale, Germany

,

Markus Wallwiener

²⁸Frauenklinik, Universitätsklinikum Heidelberg, Heidelberg, Germany

,

Paul Gass

²⁹Frauenklinik des Universitätsklinikums Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen/Europäische Metropolregion Nürnberg (CCC ER-EMN), Erlangen, Germany

,

Matthias W. Beckmann

²⁹Frauenklinik des Universitätsklinikums Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen/Europäische Metropolregion Nürnberg (CCC ER-EMN), Erlangen, Germany

› Author Affiliations

Abstract

Purpose This is an official guideline, published and coordinated by the Germany Society for Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG). Because of their rarity and heterogeneous histopathology, uterine sarcomas are challenging in terms of their clinical management and therefore require a multidisciplinary approach. To our knowledge, there are currently no binding evidence-based recommendations for the appropriate management of this heterogeneous group of tumors.

Methods This S2k guideline was first published in 2015. The update published here is once again the result of the consensus of a representative interdisciplinary committee of experts who were commissioned by the Guidelines Committee of the DGGG to carry out a systematic search of the literature on uterine sarcomas. Members of the participating professional societies achieved a formal consensus after a structured consensus process.

Recommendations 1.1 Epidemiology, classification, staging of uterine sarcomas. 1.2 Symptoms, general diagnostic workup, general pathology or genetic predisposition to uterine sarcomas. 2. Management of leiomyosarcomas. 3. Management of low-grade endometrial stromal sarcomas. 4. Management of high-grade endometrial stromal sarcoma and undifferentiated uterine sarcomas. 5. Management of adenosarcomas. 6. Rhabdomyosarcomas of the uterus in children and adolescents. 7. Follow-up of uterine sarcomas. 8. Management of morcellated uterine sarcomas. 9. Information provided to patients.

Key words

guideline - uterine sarcoma - leiomyosarcoma - endometrial stromal sarcoma - adenosarcoma - morcellation

Full Text

References

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