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Am J Perinatol 2024; 41(10): 1348-1358
DOI: 10.1055/a-1904-9194
Original Article

Clinical Correlates of Moderate-to-Severe Bronchopulmonary Dysplasia in Preterm Infants following Surgical Necrotizing Enterocolitis

Parvesh M. Garg
1   Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi
,
Melissa Pippin
1   Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi
,
Mengna Zhang
2   Department of Data Science, University of Mississippi Medical Center, Jackson, Mississippi
,
Jennifer Ware
1   Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi
,
Sarah Nelin
1   Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi
,
Jaslyn Paschal
1   Department of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi
3   Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi
,
Neha Varshney
4   Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi
,
William B. Hillegass
2   Department of Data Science, University of Mississippi Medical Center, Jackson, Mississippi
3   Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi
› Author Affiliations Funding W.B.H., MD, PhD, is supported by IDeA CTR Grant U54GM115428. P.M.G. is partially supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award number 5U54GM115428. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Abstract

Objective The aim of the study is to determine clinical correlates of moderate to severe bronchopulmonary dysplasia (BPD) in preterm infants following surgical necrotizing enterocolitis (NEC).

Study Design This is a retrospective, single-center cohort study comparing patients with moderate to severe BPD to patients with non/mild BPD among surgical NEC infants. BPD was defined by NIH 2001 consensus definition.

Results Of 92 consecutive neonates with surgical NEC, 77% (71/92) had moderate/severe BPD and 22% (21/92) had non/mild BPD. The patent ductus arteriosus (PDA) was significantly higher in those developing moderate/severe BPD (67.6% [48/71]) than non/mild BPD (28.6% [6/21]; p = 0.001). Postoperatively, infants with moderate/severe BPD had more severe acute kidney injury (AKI; 67.6 [48/71] vs. 28.6% [6/21]; p = 0.001), were intubated longer (40.5 [interquartile (IQR): 12, 59] vs. 6 days [IQR: 2, 13]; p <0.001), received more parenteral nutrition (109 [IQR: 77, 147] vs. 55 days [IQR: 19, 70]; p <0.001), developed higher surgical morbidity (46.5 [33/71] vs. 14.3% [3/21]; p = 0.008), had more intestinal failure (62.5 vs. 13.3%; p <0.001), required a longer hospital stay (161 [IQR: 112, 186] vs. 64 days [IQR: 20, 91]; p <0.001), and were more likely to need home oxygen. In a multivariable analysis, lower birth weight (OR = 0.3, [95% confidence interval (CI): 0.1–0.5]; p = 0.001), PDA (OR = 10.3, [95% CI: 1.6–65.4]; p = 0.014), and longer parenteral nutritional days (OR = 8.8; [95% CI: 2.0–43.0]; p = 0.005) were significantly and independently associated with higher odds of moderate/severe versus non-/mild BPD.

Conclusion Development of moderate/severe BPD occurred in the majority of preterm infants with surgical NEC in this consecutive series. Preterm infants with moderate/severe BPD were more likely to have a PDA before NEC. Development of moderate/severe BPD was associated with significantly greater burden and duration of postoperative morbidity following surgical NEC. Identifying surgical NEC infants at increased risk of moderate/severe BPD and developing lung protection strategies may improve surgical NEC outcomes.

Key Points

  • Three-fourths of preterm infants experienced severe lung injury following surgical NEC.

  • The infants with severe moderate/severe BPD were most likely associated with greater duration of postoperative morbidity.

  • There is need to understand and develop lung protective strategies in infants with surgical NEC.

Keywords

necrotizing enterocolitis - preterm Infants - BPD

Authors' Contributions

P.M.G. designed the study. P.M.G., M.P., M.Z., J.W., J.P., S.N., N.V., and W.B.H. collected and analyzed the data. PMG wrote the manuscript. All the authors contributed to and approved the manuscript.


Consent

Given the observational, retrospective study design, and requisite data security safeguards, the Institutional Review Board did not require patient consent.




Publication History

Received: 21 September 2021

Accepted: 15 July 2022

Accepted Manuscript online:
20 July 2022

Article published online:
16 September 2022

© 2022. Thieme. All rights reserved.

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