Dedicated to Professor Jianbo Wang on the occasion of his 60th birthday
Abstract
As a special class of cyclopropanes, gem-difluorinated cyclopropanes have many fascinating properties as a result of the gem-difluoro substitution; thus, their reactions have received much attention from the synthetic chemistry community. Recently, gem-difluorinated cyclopropanes have gradually emerged as a type of novel and unique fluorinated allylic synthon in cross-coupling reactions for the synthesis of monofluoroalkenes. Herein, we briefly summarize recent advances in transition-metal-catalyzed reactions of gem-difluorinated cyclopropanes.
1 Introduction
2 Palladium-Catalyzed Reactions with Linear Selectivity
3 Palladium-Catalyzed Reactions with Branched Selectivity
4 Other Metal-Catalyzed Reactions
5 Conclusions
Key words
gem-difluorinated cyclopropanes - monofluoroalkenes - transition-metal catalysis - allylation - C–C activation - β-fluorine elimination
