Update Breast Cancer 2022 Part 4 – Advanced-Stage Breast Cancer

Bahriye Aktas; Tanja N. Fehm; Manfred Welslau; Volkmar Müller; Diana Lüftner; Florian Schütz; Peter A. Fasching; Wolfgang Janni; Christoph Thomssen; Isabell Witzel; Erik Belleville; Michael Untch; Marc Thill; Hans Tesch; Nina Ditsch; Michael P. Lux; Maggie Banys-Paluchowski; Cornelia Kolberg-Liedtke; Andreas D. Hartkopf; Achim Wöckel; Hans-Christian Kolberg; Elmar Stickeler; Nadia Harbeck; Andreas Schneeweiss

doi:10.1055/a-1912-7362

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(09): 922-931
DOI: 10.1055/a-1912-7362

GebFra Science

Review/Übersicht

Update Breast Cancer 2022 Part 4 – Advanced-Stage Breast Cancer

Article in several languages: English | deutsch

Bahriye Aktas

¹Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany

,

Tanja N. Fehm

²Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Manfred Welslau

³Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Volkmar Müller

⁴Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Diana Lüftner

⁵Immanuel Hospital Märkische Schweiz & Medical University of Brandenburg Theodor-Fontane, Brandenburg, Buckow, Germany

,

Florian Schütz

⁶Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Peter A. Fasching

⁷Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁸Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Christoph Thomssen

⁹Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Isabell Witzel

⁴Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Erik Belleville

¹⁰ClinSol GmbH & Co KG, Würzburg, Germany

,

Michael Untch

¹¹Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Marc Thill

¹²Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main, Germany

,

Hans Tesch

¹³Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

,

Nina Ditsch

¹⁴Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Michael P. Lux

¹⁵Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Germany

,

Maggie Banys-Paluchowski

¹⁶Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

,

Cornelia Kolberg-Liedtke

¹⁷Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

,

Andreas D. Hartkopf

⁸Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Achim Wöckel

¹⁸Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Hans-Christian Kolberg

¹⁹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Elmar Stickeler

²⁰Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

,

Nadia Harbeck

²¹Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Andreas Schneeweiss

²²National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

› Author Affiliations

Abstract

For the treatment of patients with advanced HER2-negative hormone receptor-positive breast cancer, several substances have been introduced into practice in recent years. In addition, other drugs are under development. A number of studies have been published over the past year which have shown either an advantage for progression-free survival or for overall survival. This review summarizes the latest results, which have been published at current congresses or in specialist journals, and classifies them in the clinical treatment context. In particular, the importance of therapy with CDK4/6 inhibitors – trastuzumab deruxtecan, sacituzumab govitecan and capivasertib – is discussed. For trastuzumab deruxtecan, an overall survival benefit in HER2-negative breast cancer with low HER2 expression (HER2-low expression) was reported in the Destiny-Breast-04 study. Similarly, there was an overall survival benefit in the FAKTION study with capivasertib. The lack of overall survival benefit for palbociclib in the first line of therapy raises the question of clinical classification.

Key words

advanced breast cancer - chemotherapy - endocrine therapy - antibody drug conjugates

Full Text

References

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