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Synthesis 2022; 54(23): 5311-5323
DOI: 10.1055/a-1913-3105
DOI: 10.1055/a-1913-3105
paper
Multi-Component Sequential Synthesis of Dihydroorotic Acid-Based Amphiphilic Molecules
Dedicated to the memory of Tommaso Marcelli
Abstract
An efficient multicomponent sequential process, which occurs in mild condition has been exploited for the synthesis of systematically modified amphiphilic molecules where the cationic head is tethered to a lipophilic tail through a dihydroorotic acid linker. The process is operatively simple, high yielding, and flexible. Such a strategy could impact combinatorial synthesis of wide libraries of amphiphilic molecules to be tested as transfection agents and/or as antimicrobials.
Key words
multicomponent reactions - domino process - amphiphilic molecules - cationic lipids - antibacterialSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1913-3105.
- Supporting Information
Publikationsverlauf
Eingereicht: 27. Juni 2022
Angenommen nach Revision: 29. Juli 2022
Accepted Manuscript online:
29. Juli 2022
Artikel online veröffentlicht:
25. August 2022
© 2022. Thieme. All rights reserved
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