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Horm Metab Res 2022; 54(11): 760-767
DOI: 10.1055/a-1913-8223
Original Article: Endocrine Research

LINC02875 Upregulation Contributed to Poor Prognosis for the Hepatocellular Carcinoma and Progression for the Cancerous Cells

Yujian Liu‡
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Jingrui Yang‡
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Rui-Sheng Ke‡
2   Department of General Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Lupeng Wu
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Zaifa Hong
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Ping Guo
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Liuxing Feng
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
,
Zhimin Li
1   Department of Hepatobiliary Pancreatic Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
› Author Affiliations Funding This study was funded by the Fujian Natural Science Foundation (Youth Innovation) Project (No. 2020J05299) for Rui-Sheng Ke; Natural Science Foundation of Xiamen, China(No. 3502Z20209011) for Rui-Sheng Ke.
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Abstract

The prognostic implications and physiological effect of LINC02875 are unknown in hepatocellular carcinoma (HCC). We sought to examine the prognostic value of LINC02875 in HCC and assessed its role in HCC cellular function. LINC02875 expression was evaluated by RT-qPCR in HCC specimens and cell lines. LINC02875 expression was subjected to assess the correlation with clinical parameters by Chi-squared test and overall survival by Kaplan – Meier curve and Cox regression analysis. The effects of LINC02875 on the biological characteristics of HCC cells were studied by MTS and Transwell assay. LINC02875 was high-expressed in HCC, and this was associated with unfavorable clinical features and poor prognosis of HCC, especially HBV-related HCC. Knockdown of LINC02875 inhibited the proliferation, migration, and invasion of HCC cells. miR-485–5p was a downstream microRNA of LINC02875. LINC02875 affects the prognosis of HCC patients, especially HBV-related ones. LINC02875 represents a suitable therapeutic target for HCC.

Key words

LINC02875 - hepatocellular carcinoma - hepatitis B virus - prognosis


Publication History

Received: 27 April 2022

Accepted after revision: 19 July 2022

Article published online:
02 September 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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