COVID-19 in der Schwangerschaft: Ursache für eine
                    intrakranielle Blutung bei einem Frühgeborenen?

Anne Klüßendorf; Manuela F. Richter; Santje Webermann; Ralf L. Schild; Christine A. Morfeld

doi:10.1055/a-1915-5612

Zeitschrift für Geburtshilfe und Neonatologie, Table of Contents

Z Geburtshilfe Neonatol 2022; 226(05): 343-348
DOI: 10.1055/a-1915-5612

Kasuistik

COVID-19 in der Schwangerschaft: Ursache für eine intrakranielle Blutung bei einem Frühgeborenen?

COVID-19 in Pregnancy – a Risk for the Unborn Child?

Authors

Anne Klüßendorf

¹Perinatalzentrum, DIAKOVERE gGmbH, Hannover, Germany
Manuela F. Richter

²Neonatologie, KKB, Hannover, Germany
Santje Webermann

²Neonatologie, KKB, Hannover, Germany
Ralf L. Schild

¹Perinatalzentrum, DIAKOVERE gGmbH, Hannover, Germany
Christine A. Morfeld

¹Perinatalzentrum, DIAKOVERE gGmbH, Hannover, Germany

Abstract

Maternity clinics are increasingly being confronted with pregnant women suffering from Covid-19. This poses great challenges for obstetricians, since some questions have not yet been adequately researched scientifically. Not much is known about COVID-19 during pregnancy and its effects on the unborn and newborn child.

Zusammenfassung

Geburtskliniken werden zunehmend mit an Covid-19 erkrankten Schwangeren konfrontiert. Dies stellt Geburtshelfer vor große Herausforderungen, da einige Fragestellungen noch nicht ausreichend wissenschaftlich erforscht sind. Über Covid-19 während der Schwangerschaft und seine Auswirkungen auf das ungeborene und neugeborene Kind ist nicht viel bekannt.

Schlüsselwörter

anamnestische Schwangerschaftsrisiken - fetale Wachstumsrestriktion - Neonatalperiode - Frühgeburt - Infektion

Key words

fetale growth restriction - premature birth - Infection

Full Text

References

Literatur
1 Lokken EM, Huebner EM, Taylor GG. et al. Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am J Obstet Gynecol 2021; 225: 77 e1-e14
2 Antoun L, Taweel NE, Ahmed I. et al. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol 2020; 252: 559-562
3 Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS- CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res 2020; 25: 39
4 Ahlberg M, Neovius M, Saltvedt S. et al. Association of SARS-CoV-2 Test Status and Pregnancy Outcomes. JAMA 2020; 324: 1782-1785
5 Ellington S, Strid P, Tong VT. et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 769
6 Metz TD, Collier C, Hollier LM. Maternal Mortality from Coronavirus Disease 2019 (COVID-19) in the United States. Obstet Gynecol 2020; 136: 313-316
7 Kayem G, Lecarpentier E, Deruelle P. et al. A snapshot of the Covid-19 pandemic among pregnant women in France. J Gynecol Obstet Hum Reprod 2020; 49: 101826
8 Kucirka LM, Norton A, Sheffield J. Severity of COVID-19 In Pregnancy: A Review of Current Evidence. Am J Reprod Immunol 2020; 84: e13332
9 Breslin N, Baptiste C, Gyamfi-Bannerman C. et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM 2020; 2: 100118
10 Gao YJ, Ye L, Zhang JS. et al. Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. BMC Infect Dis 2020; 20: 564
11 Hessami K, Homayoon N, Hashemi A. et al. COVID-19 and maternal, fetal and neonatal mortality: a systematic review. J Matern Fetal Neonatal Med 2020; 16: 1-6
12 Barbero P, Mugüerza L, Herraiz I. et al. SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19. J Matern Fetal Neonatal Med 2020; 20: 1-7
13 Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020; 99: 823-829
14 Dashraath P, Wong JLJ, Lim MXK. et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol 2020; 222: 521-531
15 Allotey J, Stallings E, Bonet M. et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020; 370: m3320
16 Hagenbeck C, Hecher K, Pecks U. et al. Empfehlungen zu SARS-CoV-2/COVID-19 in Schwangerschaft, Geburt und Wochenbett. Update November 2021. Eine gemeinsame Stellungnahme von Deutscher Gesellschaft für Gynäkologie und Geburtshilfe e. V. (DGGG), Deutscher Gesellschaft für Perinatale Medizin e. V. (DGPM) und weiteren Fachgesellschaften. Im Internet: https://www.dggg.de/stellungnahmen/empfehlungen-zu-sars-cov-2covid-19-in-schwangerschaft-geburt-und-wochenbett-november-2021
17 Khalil A, Kalafat E, Benlioglu C. et al. SARS-CoV-2 infection in pregnancy: A systematic review and meta-analysis of clinical features and pregnancy outcomes. EClinicalMedicine 2020; 25: 100446
18 The Fetal Medicine Foundation. Assessment: Fetal Growth. Im Internet: https://fetalmedicine.org/research/doppler
19 The Fetal Medicine Foundation. Assessment: Fetal Doppler. Im Internet: https://fetalmedicine.org/research/doppler
20 Weichert J, Gembicki M, Kreiselmaier P. et al. Fetale intrakranielle Blutungen – Diagnose, Risikofaktoren und Outcome – Zusammenstellung von 282 pränatalen Fällen. Geburtshilfe Frauenheilkd 2016; 76: P442
21 Engert V, Siauw C, Stock A. et al. Severe Brain Damage in a Moderate Preterm Infant as Complication of Post-COVID-19 Response during Pregnancy. Neonatology 2021; 118: 505-508
22 Song WC, FitzGerald GA. COVID-19 microangiopathy, hemostatic activation and complement. J Clin Invest 2020; 130: 3950-3953
23 Varga Z, Flammer AJ, Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 2020; 395: 1417-1418
24 McGonagle D, Bridgewood C, Ramanan AV. et al. COVID-19 vasculitis and novel vasculitis mimics. Lancet Rheumatol 2021; 3: e224-e233
25 Giordano G, Petrolini C, Corradini E. et al. COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome in five cases. Diagnostic Pathology 2021; 16: 88
26 Shanes ED, Mithal LB, Otero S. et al. Placental Pathology in Covid-19. Am J Clin Pathol 2020; 154: 23-32
27 Stock SJ, Carruthers J, Calvert C. et al. SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nat Med 2022; 28: 504-512
28 Voigt M. et al. Kurzmitteilung zu den Perzentilwerten für die Körpermaße der Neugeborenen. Z Geburtsh Neonatol 2010; 214: 24-29
29 Kallash M, Ingelfinger JR, Vehasakari VM. Perinatal Programming and Blood Pressure. In: Pediatric Hypertension. 3. Aufl. Springer; 2013. DOI: 10.1007/978-1-62703-490-6_7