A new biomarker for lung metastasis in non-seminomatous testicular cancer: De Ritis Ratio

Abstract

Purpose We aimed to show that the De Ritis Ratio (DRR) may be a new biomarker for lung metastasis in non-seminomatous Testicular Cancers (TC).

Material and Methods Patients who underwent radical orchiectomy due to TC between January 2010 and January 2021 were included in the study. Demographic characteristics, preoperative laboratory and radiological findings and pathological data of the patients were recorded. The DRR was calculated from preoperative peripheral blood analysis.

Results A total of 124 patients with non-seminomatous TC were included. Mean patient age was 30.67±7.45 years, and the mean tumour diameter was 4.69±2.55 cm. 61 patients had T1, 51 had T2, and 12 had T3 disease. 42 of them had lung metastasis; 82 of them had no lung metastasis. The optimal DRR threshold was 1.21 for lung metastasis. [Area Under the Curve (AUC): 0.724 with a sensitivity of 81% and specificity of 74%]. DRR was determined as an independent prognostic factor for lung metastasis in univariate and multivariate analyses (p=0.002).

Conclusions A high preoperative DRR can be used to detect the presence of lung metastases in non-seminomatous TCs.

Zusammenfassung

Unser Ziel war es zu zeigen, dass De Ritis Ratio ein neuer Biomarker für Lungenmetastasen bei nicht-seminomatösem Hodenkrebs sein könnte. Patienten, die sich zwischen Januar 2010 und Januar 2021 einer radikalen Orchiektomie aufgrund von Hodenkrebs unterzogen hatten, wurden in die Studie eingeschlossen. Demografische Merkmale, präoperative Labor- und radiologische Befunde sowie pathologische Daten der Patienten wurden erfasst. Die De Ritis Ratio wurde aus der präoperativen peripheren Blutanalyse berechnet. Insgesamt wurden 124 Patienten mit nicht-seminomatösem Hodenkrebs eingeschlossen. Das Durchschnittsalter der Patienten betrug 30,67 ± 7,45 Jahre und der mittlere Tumordurchmesser 4,69 ± 2,55 cm. 61 Patienten hatten eine T1-, 51 eine T2-, 12 eine T3-Erkrankung. 42 von ihnen hatten Lungenmetastasen, 82 von ihnen hatten keine Lunge Metastasierung.

Der optimale De-Ritis-Ratio-Schwellenwert lag bei 1,21 für Lungenmetastasen. [Fläche unter der Kurve (AUC): 0,724 mit einer Sensitivität von 81% und einer Spezifität von 74%]. De Ritis Ratio wurde als unabhängiger Prognosefaktor für Lungenmetastasen in univariaten und multivariaten Analysen ermittelt (p=0,002).

Die präoperative hohe De Ritis Ratio kann verwendet werden, um das Vorhandensein von Lungenmetastasen bei nicht-seminomatösem Hodenkrebs nachzuweisen.

Schlüsselwörter

Hodenkrebs - De Ritis Ratio - Lungenmetastasen - Aspartat-Aminotransferase - Alanin-Aminotransferase

Keywords

testicular cancer - lung metastasis - aspartate aminotransferase - alanin aminotransferase - De Ritis ratio

Publikationsverlauf

Eingereicht: 03. Juli 2022

Angenommen: 14. August 2022

Artikel online veröffentlicht:
27. Oktober 2022

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