Download PDF
J Neurol Surg A Cent Eur Neurosurg 2025; 86(02): 177-181
DOI: 10.1055/a-1942-2310
Original Article

Analysis of Benign Retroperitoneal Schwannomas: A Single-center Experience

Maosheng Tang 
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
,
Wenqing Liu
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
,
Xiaobing Chen
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
,
Boyuan Zou
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
,
Shibo Liu
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
,
Mengmeng Xiao
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
,
Chenghua Luo
1   Department of Retroperitoneal Tumors, Peking University International Hospital, Changping District, Beijing, China
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Background Retroperitoneal schwannomas are rare. The purpose of this study was to present our experience with the diagnosis and treatment of 67 such tumors.

Methods We retrospectively analyzed 67 patients with retroperitoneal schwannoma admitted to the Peking University International Hospital from 2015 to 2021.

Results Thirty-seven of the 67 patients had no obvious clinical symptoms. Complete excision was obtained in 62 and subtotal excision in 5 cases. In7 cases, tumor resection was combined with organ resection. The intraoperative blood loss was 300 ml (20–9,000 ml), the maximum size of the tumor was 9 cm (2.5–26 cm), and postoperative complication occurred in six cases (9.0%). Compared with abdominal retroperitoneal tumors, pelvic retroperitoneal tumors had larger tumor volume, more bleeding, higher proportion of block resection, and longer postoperative hospitalization time (p < 0.05). The residual mass progressed slowly in five patients with subtotal resection, and no obvious malignant transformation occurred.

Conclusion Complete resection of a retroperitoneal schwannoma can achieve a good long-term prognosis. Residual tumor after surgery progresses slowly and rarely become malignant. We recommend early resection after the discovery of a pelvic retroperitoneal schwannoma.

Keywords

schwannoma - retroperitoneal neoplasms - postoperative complications


Publication History

Received: 11 May 2022

Accepted: 13 September 2022

Accepted Manuscript online:
13 September 2022

Article published online:
04 November 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Vijayan SKL. Retroperitoneal schwannoma: an atypical presentation. J Clin Diagn Res 2014; 8 (10) ND22-ND23
    PubMedSearch in Google Scholar
  • 2 Li Q, Gao C, Juzi JT, Hao X. Analysis of 82 cases of retroperitoneal schwannoma. ANZ J Surg 2007; 77 (04) 237-240
    CrossrefPubMedSearch in Google Scholar
  • 3 Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S. Overview of primary adult retroperitoneal tumours. Eur J Surg Oncol 2020; 46 (09) 1573-1579
    CrossrefPubMedSearch in Google Scholar
  • 4 Harhar M, Ramdani A, Bouhout T, Serji B, El Harroudi T. Retroperitoneal schwannoma: two rare case reports. Cureus 2021; 13 (02) e13456
    CrossrefPubMedSearch in Google Scholar
  • 5 Tortorelli AP, Rosa F, Papa V. et al. Retroperitoneal schwannomas: diagnostic and therapeutic implications. Tumori 2007; 93 (03) 312-315
    CrossrefPubMedSearch in Google Scholar
  • 6 Strauss DC, Qureshi YA, Hayes AJ, Thomas JM. Management of benign retroperitoneal schwannomas: a single-center experience. Am J Surg 2011; 202 (02) 194-198
    CrossrefPubMedSearch in Google Scholar
  • 7 Transatlantic Australasian Retroperitoneal Sarcoma Working Group. Intercontinental collaborative experience with abdominal, retroperitoneal and pelvic schwannomas. Br J Surg 2020; 107 (04) 452-463
    CrossrefPubMedSearch in Google Scholar
  • 8 Ogose A, Kawashima H, Hatano H. et al. The natural history of incidental retroperitoneal schwannomas. PLoS One 2019; 14 (04) e0215336
    CrossrefPubMedSearch in Google Scholar
  • 9 Theodosopoulos T, Stafyla VK, Tsiantoula P. et al. Special problems encountering surgical management of large retroperitoneal schwannomas. World J Surg Oncol 2008; 6 (107): 107
    CrossrefPubMedSearch in Google Scholar
  • 10 Hughes MJ, Thomas JM, Fisher C, Moskovic EC. Imaging features of retroperitoneal and pelvic schwannomas. Clin Radiol 2005; 60 (08) 886-893
    CrossrefPubMedSearch in Google Scholar
  • 11 Mastoraki A, Toska F, Tsiverdis I. et al. Retroperitoneal schwannomas: dilemmas in diagnostic approach and therapeutic management. J Gastrointest Cancer 2013; 44 (04) 371-374
    CrossrefPubMedSearch in Google Scholar
  • 12 Heinen C, Schmidt T, Kretschmer T. Decision making in retroperitoneal nerve sheath and nerve-associated tumors: a modular approach. Neurosurgery 2020; 87 (03) E359-E369
    CrossrefPubMedSearch in Google Scholar
  • 13 Ahlawat S, Blakeley JO, Langmead S, Belzberg AJ, Fayad LM. Current status and recommendations for imaging in neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. Skeletal Radiol 2020; 49 (02) 199-219
    CrossrefPubMedSearch in Google Scholar
  • 14 Jain A, Baracco R, Kapur G. Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management. Pediatr Nephrol 2020; 35 (04) 581-594
    CrossrefPubMedSearch in Google Scholar
  • 15 Shen Y, Zhong Y, Wang H. et al. MR imaging features of benign retroperitoneal paragangliomas and schwannomas. BMC Neurol 2018; 18 (01) 1
    CrossrefPubMedSearch in Google Scholar
  • 16 Xiao J, Zhao Z, Li B, Zhang T. Primary retroperitoneal ganglioneuroma: a retrospective cohort study of 32 patients. Front Surg 2021; 8: 642451
    CrossrefPubMedSearch in Google Scholar
  • 17 McMenamin ME, Fletcher CDM. Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. Am J Surg Pathol 2001; 25 (01) 13-25
    CrossrefPubMedSearch in Google Scholar
  • 18 Song JY, Kim SY, Park EG. et al. Schwannoma in the retroperitoneum. J Obstet Gynaecol Res 2007; 33 (03) 371-375
    CrossrefPubMedSearch in Google Scholar
  • 19 Ohsawa M, Miguchi M, Yoshimitsu M. et al. Laparoscopic excision of a retroperitoneal schwannoma: a case report. Asian J Endosc Surg 2019; 12 (02) 192-196
    CrossrefPubMedSearch in Google Scholar