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DOI: 10.1055/a-1944-9623
Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of Genus Hericium
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 21K05407.
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Abstract
This Short Review covers the total synthesis of tetraketide-based meroterpenoids, i.e. geranyl-resorcinols, isolated from the mushrooms of genus Hericium. Some of these compounds are believed to be involved in the unique health-promoting effects of Hericium erinaceus. Herein, more than seventy natural products identified so far have been classified into seven-types based on both assumed biosynthetic pathways and chemical structures, and the successful total syntheses are summarized according to the structural type.
1 Introduction
2 Pioneering Synthetic Study
3 Total Synthesis of Geranyl-Resorcinol with a Geranyl Side Chain (Types 1, 3, and 6)
4 Total Synthesis of Geranyl-Resorcinol with an Oxidized Geranyl-Derived Side Chain (Types 2, 4, and 7)
5 Conclusion
Key words
mushroom - Hericium erinaceus - meroterpenoid - geranyl-resorcinol - total synthesis - biosynthetic pathwayPublication History
Received: 01 August 2022
Accepted after revision: 15 September 2022
Accepted Manuscript online:
15 September 2022
Article published online:
28 November 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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