Affenpocken – eine neue Geschlechtskrankheit

Zusammenfassung

Aktuell steht zur Diskussion, wie und über welchen Verbreitungsweg es zu der deutlichen Zunahme von Affenpocken-Infektionen in Europa gekommen ist. Anhand unserer zweier Fallbeispiele möchten wir die histopathologischen Charakteristika und Unterschiede zu anderen viralen Infektionen wie etwa Schafpocken- oder Herpes simplex-Infektionen zeigen. Zudem möchten wir aufgrund der klinisch ähnlichen Präsentation von Affenpocken zu anderen STDs (sexual transmitted diseases) bezüglich genitaler Ulzerationen und Lymphadenopathien sowie der häufigen Koinfektionen mit weiteren STDs die differenzialdiagnostische Inkludierung in die gängige STD-Routinediagnostik vorschlagen.

Abstract

It is under discussion how and via which route the spread of monkeypox infections has increased in Europe. We are showing with our two monkeypox case reports the histopathological characteristics and differences to other viral infections, such as sheep pox or herpes simplex infections. In addition, due to the clinically similar presentation of monkeypox to other STDs with genital ulcerations and lymphadenopathies, as well as the frequent coinfections with other STDs, we would like to suggest the differential diagnostic inclusion in the common STD routine diagnostics.

Schlüsselwörter

Dermatologie - Affenpocken - STD - Histologie

Keywords

dermatology - monkeypox - STD - histology

Publikationsverlauf

Artikel online veröffentlicht:
11. November 2022

• Literatur

• 1 Kaler J, Hussain A, Flores G. et al. Monkeypox: A Comprehensive Review of Transmission, Pathogenesis, and Manifestation. Cureus 2022; 14: e26531
• 2 Saxena SK, Ansari S, Maurya VK. et al. Re-emerging human monkeypox: A major public-health debacle. J Med Virol 2022;
• 3 Damon IK. Status of human monkeypox: clinical disease, epidemiology and research. Vaccine 2011; 29 (Suppl. 04) D54-D59
• 4 Gong Q, Wang C, Chuai X. et al. Monkeypox virus: a re-emergent threat to humans. Virol Sin 2022; 37: 477-482
• 5 Kumar N, Acharya A, Gendelman HE. et al. The 2022 outbreak and the pathobiology of the monkeypox virus. J Autoimmun 2022; 131: 102855
• 6 Quarleri J, Delpino MV, Galvan V. Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries. Geroscience 2022;
• 7 Selb R, Werber D, Falkenhorst G. et al. A shift from travel-associated cases to autochthonous transmission with Berlin as epicentre of the monkeypox outbreak in Germany, May to June 2022. Euro Surveill 2022; 27: 2200499
• 8 Kupferschmidt K. Why monkeypox is mostly hitting men who have sex with men. Science 2022; 376: 1364-1365
• 9 Peiró-Mestres A, Fuertes I, Camprubí-Ferrer D. et al. Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients, Barcelona, Spain, May to June 2022. Euro Surveill 2022; 27: 2200503
• 10 Lapa D, Carletti F, Mazzotta V. et al. Monkeypox virus isolation from a semen sample collected in the early phase of infection in a patient with prolonged seminal viral shedding. Lancet Infect Diseases 2022; 22: 1267-1269