Bilateral Upper Eyelid Swelling with Abscess under Treatment with Etanercept

Abstract

We report the case of a 66-year-old female patient with rheumatoid arthritis and bilateral upper eyelid abscess under treatment with etanercept. Because bilateral upper lid abscesses due to a systemic cause are rare and cases of abscess formation under treatment with etanercept have been described in the literature, we discuss a possible connection between the bilateral upper lid abscess and the existing immunosuppressive medication.

Key words

plastic surgery - lids - orbit

Publication History

Received: 28 June 2022

Accepted: 12 September 2022

Article published online:
23 December 2022

• References/Literatur

• 1 Kampik A, Grehn F. Hrsg. Augenärztliche Differenzialdiagnose. 2. Aufl.. Stuttgart: Thieme; 2008
• 2 Lang GK, Lang GE. Augenheilkunde Essentials. Stuttgart: Thieme; 2015
• 3 Adriana ID, Cornel S, Mihaela TC. et al. Upper eyelid abscess as a late complication of frontal sinus trauma. Rom J Ophthalmol 2015; 59: 269-272
• 4 Cavicchio A, Freitag SK, Rabinovich A. et al. Eyelid abscess arising from an epidermal inclusion cyst. Ophthalmic Surg Lasers Imaging 2010;
• 5 Casady DR, Zobal-Ratner JL, Meyer DR. Eyelid abscess as a presenting sign of occult sinusitis. Ophthalmic Plast Reconstr Surg 2005; 21: 368-370
• 6 Bacorn C, Kim E, Lin LK. Eyelid abscess masking underlying sebaceous cell carcinoma. Orbit 2020; 39: 212-216
• 7 European Medicines Agency (EMA). Enbrel: EPAR – Product Information (11.09.2009). Im Internet (Stand: 01.09.2022): https://www.ema.europa.eu/en/documents/product-information/enbrel-epar-product-information_en.pdf
• 8 Borrás-Blasco J, Nuñez-Cornejo C, Gracia-Perez A. et al. Parapharyngeal abscess in a patient receiving etanercept. Ann Pharmacother 2007; 41: 341-344
• 9 DʼAmore M, Minenna G, Favoino E. et al. Phlegmonous abscess associated with etanercept therapy. Panminerva Med 2006; 48: 199-200
• 10 Fitch PG, Cron RQ. Septic abscess in a child with juvenile idiopathic arthritis receiving anti-tumor necrosis factor-alpha. J Rheumatol 2006; 33: 825 author reply 826
• 11 Kasirye Y, Epperla N, Manne JR. et al. Brain abscesses complicating acute pneumococcal meningitis during etanercept therapy. Clin Med Res 2012; 10: 230-235
• 12 Phillips K, Husni ME, Karlson EW. et al. Experience with etanercept in an academic medical center: are infection rates increased?. Arthritis Rheum 2002; 47: 17-21
• 13 Mehta DK, Sahnikamal. Ashok P. Bilateral tubercular lid abscess – a case report. Indian J Ophthalmol 1989; 37: 98
• 14 von Tirpitz C, Buchwald HJ, Lang GK. et al. Simultaneous onset of pyoderma gangrenosum and bitemporal abscesses of the upper eyelids during a flare of ulcerative colitis. Inflamm Bowel Dis 1998; 4: 98-100
• 15 Sunderkötter C, Becker K, Eckmann C. et al. S2k-Leitlinie Haut- und Weichgewebeinfektionen Auszug aus „Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen – Update 2018“. J Dtsch Dermatol Ges 2019; 17: 345-371
• 16 Daum RS, Miller LG, Immergluck L. et al. A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses. N Engl J Med 2017; 376: 2545-2555
• 17 Meyer R. Unkomplizierte Hautabszesse: Antibiotika können die Abheilung beschleunigen. Dtsch Arztebl Ausg A 2017; 114: A-1489