SOP Vakzininduzierte immunogene thrombotische Thrombozytopenie

In dieser Rubrik stellen wir Standard Operating Procedures (SOPs) für perioperativ und intensivmedizinisch relevante Prozesse vor. Die Form ist eher im Sinne einer Schablone zu verstehen als – durchaus subjektiv gefärbte – Anregung, eigene, auf lokale Gegebenheiten adaptierte stationsinterne SOPs zu entwerfen und zu implementieren.

Publication History

Article published online:
06 December 2022

• Literatur

• 1 Greinacher A, Thiele T, Warkentin TE. et al. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. N Engl J Med 2021; 384: 2092-2101
• 2 Pavord S, Scully M, Hunt BJ. et al. Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis. N Engl J Med 2021; 385: 1680-1689
• 3 Perry RJ, Tamborska A, Singh B. et al. Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study. Lancet 2021; 398: 1147-1156
• 4 Schultz NH, Sorvoll IH, Michelsen AE. et al. Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021; 384: 2124-2130
• 5 Scully M, Singh D, Lown R. et al. Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021; 384: 2202-2211
• 6 Tiede A, Sachs UJ, Czwalinna A. et al. Prothrombotic immune thrombocytopenia after COVID-19 vaccine. Blood 2021; 138: 350-353
• 7 Muir KL, Kallam A, Koepsell SA. et al. Thrombotic Thrombocytopenia after Ad26.COV2.S Vaccination. N Engl J Med 2021; 384: 1964-1965
• 8 Huynh A, Kelton JG, Arnold DM. et al. Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia. Nature 2021; 596: 565-569
• 9 Greinacher A. Heparin-Induced Thrombocytopenia. N Engl J Med 2015; 373: 1883-1884
• 10 Salih F, Schonborn L, Kohler S. et al. Vaccine-Induced Thrombocytopenia with Severe Headache. N Engl J Med 2021; 385: 2103-2105
• 11 Greinacher A, Langer F, Makris M. et al. Vaccine-induced immune thrombotic thrombocytopenia (VITT) - update on diagnosis and management considering different resources. J Thromb Haemost 2022; 20: 149-156
• 12 Vayne C, Rollin J, Gruel Y. et al. PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia. N Engl J Med 2021; 385: 376-378
• 13 Platton S, Bartlett A, MacCallum P. et al. Evaluation of laboratory assays for anti-platelet factor 4 antibodies after ChAdOx1 nCOV-19 vaccination. J Thromb Haemost 2021; 19: 2007-2013
• 14 Sachs UJ, Cooper N, Czwalinna A. et al. PF4-Dependent Immunoassays in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: Results of an Interlaboratory Comparison. Thromb Haemost 2021; 121: 1622-1627
• 15 Thiele T, Weisser K, Schonborn L. et al. Laboratory confirmed vaccine-induced immune thrombotic thrombocytopenia: Retrospective analysis of reported cases after vaccination with ChAdOx-1 nCoV-19 in Germany. Lancet Reg Health Eur 2022; 12: 100270
• 16 Graf T, Thiele T, Klingebiel R. et al. Immediate high-dose intravenous immunoglobulins followed by direct thrombin-inhibitor treatment is crucial for survival in Sars-Covid-19-adenoviral vector vaccine-induced immune thrombotic thrombocytopenia VITT with cerebral sinus venous and portal vein thrombosis. J Neurol 2021; 268: 4483-4485
• 17 Oldenburg J, Klamroth R, Langer F. et al. Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH. Hamostaseologie 2021; 41: 184-189
• 18 Bourguignon A, Arnold DM, Warkentin TE. et al. Adjunct Immune Globulin for Vaccine-Induced Immune Thrombotic Thrombocytopenia. N Engl J Med 2021; 385: 720-728
• 19 Gunther A, Bramer D, Pletz MW. et al. Complicated Long Term Vaccine Induced Thrombotic Immune Thrombocytopenia-A Case Report. Vaccines (Basel) 2021; 9: 1344
• 20 Gessler F, Schmitz AK, Dubinski D. et al. Neurosurgical Considerations Regarding Decompressive Craniectomy for Intracerebral Hemorrhage after SARS-CoV-2-Vaccination in Vaccine Induced Thrombotic Thrombocytopenia-VITT. J Clin Med 2021; 10: 2777
• 21 Bundesärztekammer. Querschnitts-Leitlinien (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten – Gesamtnovelle 2020. Accessed January 05, 2022 at: https://www.bundesaerztekammer.de/aerzte/medizin-ethik/wissenschaftlicher-beirat/veroeffentlichungen/haemotherapietransfusionsmedizin/querschnitt-leitlinie/
• 22 Patriquin CJ, Laroche V, Selby R. et al. Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia. N Engl J Med 2021; 385: 857-859
• 23 Schonborn L, Thiele T, Kaderali L. et al. Decline in Pathogenic Antibodies over Time in VITT. N Engl J Med 2021; 385: 1815-1816