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CC BY-NC-ND 4.0 · Planta Med 2023; 89(06): 637-662
DOI: 10.1055/a-1955-4624
Natural Product Chemistry & Analytical Studies
Reviews

Phyllobilins – Bioactive Natural Products Derived from Chlorophyll – Plant Origins, Structures, Absorption Spectra, and Biomedical Properties

Cornelia A. Karg
1   Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilian University of Munich, Germany
,
Masahiko Taniguchi
2   Department of Chemistry, North Carolina State University, Raleigh, USA
,
Jonathan S. Lindsey
2   Department of Chemistry, North Carolina State University, Raleigh, USA
,
Simone Moser 
1   Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilian University of Munich, Germany
› Author AffiliationsSupported by: Division of Chemcal Sciences, Geosciences and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy DE-FG02-05ER15661
Supported by: Deutsche Forschungsgemeinschaft 448289381
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Abstract

Phyllobilins are open-chain products of the biological degradation of chlorophyll a in higher plants. Recent studies reveal that phyllobilins exert anti-oxidative and anti-inflammatory properties, as well as activities against cancer cells, that contribute to the human health benefits of numerous plants. In general, phyllobilins have been overlooked in phytochemical analyses, and – more importantly – in the analyses of medicinal plant extracts. Nevertheless, over the past three decades, > 70 phyllobilins have been identified upon examination of more than 30 plant species. Eight distinct chromophoric classes of phyllobilins are known: phyllolumibilins (PluBs), phylloleucobilins (PleBs), phylloxanthobilins (PxBs), and phylloroseobilins (PrBs)–each in type-I or type-II groups. Here, we present a database of absorption and fluorescence spectra that has been compiled of 73 phyllobilins to facilitate identification in phytochemical analyses. The spectra are provided in digital form and can be viewed and downloaded at www.photochemcad.com. The present review describes the plant origin, molecular structure, and absorption and fluorescence features of the 73 phyllobilins, along with an overview of key medicinal properties. The review should provide an enabling tool for the community for the straightforward identification of phyllobilins in plant extracts, and the foundation for deeper understanding of these ubiquitous but underexamined plant-derived micronutrients for human health.

Key words

Bioactivity - chlorophyll catabolites - micronutrients - phyllobilins - phytochemicals - spectral database


Publication History

Received: 27 June 2022

Accepted after revision: 04 September 2022

Accepted Manuscript online:
05 October 2022

Article published online:
08 December 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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