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CC BY-NC-ND 4.0 · Int J Sports Med 2023; 44(03): 177-183
DOI: 10.1055/a-1960-3407
Physiology & Biochemistry

Both Hypoxia and Hypobaria Impair Baroreflex Sensitivity but through Different Mechanisms

Nicolas Bourdillon 
1   ISSUL, institute of sports sciences, Université de Lausanne, Lausanne, Switzerland
,
Mathias Rolland Aebi
1   ISSUL, institute of sports sciences, Université de Lausanne, Lausanne, Switzerland
2   Wissenschaft & Technologie, armasuisse, Thun, Switzerland
,
Bengt Kayser
1   ISSUL, institute of sports sciences, Université de Lausanne, Lausanne, Switzerland
,
Denis Bron
1   ISSUL, institute of sports sciences, Université de Lausanne, Lausanne, Switzerland
,
Gregoire P Millet
3   ISSUL, University of Lausanne, Lausanne, Switzerland
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Abstract

Baroreflex sensitivity (BRS) is a measure of cardiovagal baroreflex and is lower in normobaric and hypobaric hypoxia compared to normobaric normoxia. The aim of this study was to assess the effects of hypobaria on BRS in normoxia and hypoxia. Continuous blood pressure and ventilation were recorded in eighteen seated participants in normobaric normoxia (NNx), hypobaric normoxia (HNx), normobaric hypoxia (NHx) and hypobaric hypoxia (HHx). Barometric pressure was matched between NNx vs. NHx (723±4 mmHg) and HNx vs. HHx (406±4 vs. 403±5 mmHg). Inspired oxygen pressure (PiO2) was matched between NNx vs. HNx (141.2±0.8 vs. 141.5±1.5 mmHg) and NHx vs. HHx (75.7±0.4 vs. 74.3±1.0 mmHg). BRS was assessed using the sequence method. BRS significantly decreased in HNx, NHx and HHx compared to NNx. Heart rate, mean systolic and diastolic blood pressures did not differ between conditions. There was the specific effect of hypobaria on BRS in normoxia (BRS was lower in HNx than in NNx). The hypoxic and hypobaric effects do not add to each other resulting in comparable BRS decreases in HNx, NHx and HHx. BRS decrease under low barometric pressure requires future studies independently controlling O2 and CO2 to identify central and peripheral chemoreceptors’ roles.

Key words

baroreflex sensitivity - blood pressure - heart rate - hypobaria - hypoxia - hypocapnia


Publikationsverlauf

Eingereicht: 27. April 2022

Angenommen: 04. September 2022

Artikel online veröffentlicht:
01. Dezember 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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