Individualized Treatment for Glaucoma Patients with Diabetes mellitus

Abstract

Glaucoma and diabetes mellitus are two common chronic diseases in Europe and worldwide which require intensive therapy. Various pathophysiological mechanisms have been discussed which favour the development of glaucoma, especially in the presence of diabetes mellitus. Medicinal and surgical adjustment of intraocular pressure is associated with some limitations in patients with diabetes mellitus, for example, filtering interventions show lower success rates than in non-diabetic glaucoma patients. Besides pure ophthalmological endocrinological therapy, the psychological burden of two chronic diseases should also be considered and included in the individual therapy plan.

Key words

glaucoma - diabetes mellitus - chronic disease

• References/Literatur

• 1 Tham YC, Li X, Wong TY. et al. Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. Ophthalmology 2014; 121: 2081-2090
• 2 Bourne RRA, Taylor HR, Flaxman SR. et al. Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990–2010: A Meta-Analysis. PLoS One 2016; 11: e0162229
• 3 Jonas JB, Aung T, Bourne RR. et al. Glaucoma. Lancet 2017; 390: 2183-2193
• 4 International Diabetes Federation. ed. IDF Diabetes Atlas, Tenth Edition. Diabetes around the World in 2021. Zugriff am 13. August 2022 unter: https://diabetesatlas.org/atlas/tenth-edition/
• 5 American Diabetes Association. Standards of Medical Care in Diabetes–2019 Abridged for Primary Care Providers. Clin Diabetes 2019; 37: 11-34
• 6 Teo ZL, Tham YC, Yu M. et al. Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045: Systematic Review and Meta-analysis. Ophthalmology 2021; 128: 1580-1591
• 7 Virtanen A, Haukka J, Loukovaara S. et al. Diabetes mellitus and risk of open-angle glaucoma–A population-based follow-up study. Acta Ophthalmol 2022;
• 8 Deutsche Diabetes Gesellschaft (DDG), diabetesDE – Deutsche Diabetes-Hilfe. Hrsg. Deutscher Gesundheitsbericht Diabetes 2022. Zugriff am 27. September 2022 unter: https://www.diabetesde.org/system/files/documents/gesundheitsbericht_2022.pdf
• 9 Li Y, Mitchell W, Elze T. et al. Association Between Diabetes, Diabetic Retinopathy, and Glaucoma. Curr Diab Rep 2021; 21: 38
• 10 Hou H, Moghimi S, Baxter SL. et al. Is Diabetes Mellitus a Blessing in Disguise for Primary Open-angle Glaucoma?. J Glaucoma 2021; 30: 1-4
• 11 Wang X, Xu G, Wang W. et al. Changes in corneal biomechanics in patients with diabetes mellitus: a systematic review and meta-analysis. Acta Diabetol 2020; 57: 973-981
• 12 Khawaja AP, Crabb DP, Jansonius NM. The role of ocular perfusion pressure in glaucoma cannot be studied with multivariable regression analysis applied to surrogates. Invest Ophthalmol Vis Sci 2013; 54: 4619-4620
• 13 Tielsch JM, Katz J, Sommer A. et al. Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol 1995; 113: 216-221
• 14 Charlson ME, de Moraes CG, Link A. et al. Nocturnal systemic hypotension increases the risk of glaucoma progression. Ophthalmology 2014; 121: 2004-2012
• 15 Su DHW, Wong TY, Wong WL. et al. Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. Ophthalmology 2008; 115: 964-968.e1
• 16 Shami SK, Chittenden SJ. Microangiopathy in diabetes mellitus: II. Features, complications and investigation. Diabetes Res 1991; 17: 157-168
• 17 Bonaventure N, Roussel G, Wioland N. [Stereospecificity of the action of alpha-aminoadipic acid on the retina: a morphological and electrophysiological study]. C R Seances Acad Sci III 1983; 296: 457-462
• 18 Yanagi M, Kawasaki R, Wang JJ. et al. Vascular risk factors in glaucoma: a review. Clin Exp Ophthalmol 2011; 39: 252-258
• 19 Sato T, Roy S. Effect of high glucose on fibronectin expression and cell proliferation in trabecular meshwork cells. Invest Ophthalmol Vis Sci 2002; 43: 170-175
• 20 Rodrigues GB, Abe RY, Zangalli C. et al. Neovascular glaucoma: a review. Int J Retina Vitreous 2016; 2: 26
• 21 Havens SJ, Gulati V. Neovascular Glaucoma. Dev Ophthalmol 2016; 55: 196-204
• 22 Zhou M, Wang W, Huang W. et al. Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. PLoS One 2014; 9: e102972
• 23 Zhao YX, Chen XW. Diabetes and risk of glaucoma: systematic review and a Meta-analysis of prospective cohort studies. Int J Ophthalmol 2017; 10: 1430-1435
• 24 Kjærsgaard M, Grauslund J, Vestergaard AH. et al. Relationship between Diabetic Retinopathy and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis. Ophthalmic Res 2022; 65: 377-386
• 25 Hou H, Shoji T, Zangwill LM. et al. Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients. Am J Ophthalmol 2018; 189: 1-9
• 26 European Glaucoma Society (EGS). European Glaucoma Society Guidelines – 5th ed. 2021. Zugriff am 22. Oktober 2022 unter: https://www.eugs.org/eng/guidelines.asp
• 27 Przezak A, Bielka W, Pawlik A. Hypertension and Type 2 Diabetes–The Novel Treatment Possibilities. Int J Mol Sci 2022; 23: 6500
• 28 Siklos P, Henderson RG. Severe acidosis from acetazolamide in a diabetic patient. Curr Med Res Opin 1979; 6: 284-286
• 29 Feldman-Billard S, Du Pasquier-Fediaevsky L, Héron E. Hyperglycemia after repeated periocular dexamethasone injections in patients with diabetes. Ophthalmology 2006; 113: 1720-1723
• 30 Zhang YP, Peng XY, Li ZH. et al. Hyperglycemic effects of a periocular dexamethasone injection in diabetic patients after vitreoretinal surgery. Biomed Environ Sci 2012; 25: 311-316
• 31 Lin HC, Stein JD, Nan B. et al. Association of Geroprotective Effects of Metformin and Risk of Open-Angle Glaucoma in Persons With Diabetes Mellitus. JAMA Ophthalmol 2015; 133: 915-923
• 32 Kim YS, Kim M, Choi MY. et al. Metformin protects against retinal cell death in diabetic mice. Biochem Biophys Res Commun 2017; 492: 397-403
• 33 Zhang X, Hou A, Cao J. et al. Association of Diabetes Mellitus With Postoperative Complications and Mortality After Non-Cardiac Surgery: A Meta-Analysis and Systematic Review. Front Endocrinol (Lausanne) 2022; 13: 841256
• 34 Law SK, Hosseini H, Saidi E. et al. Long-term outcomes of primary trabeculectomy in diabetic patients with primary open angle glaucoma. Br J Ophthalmol 2013; 97: 561-566
• 35 Hugkulstone CE, Smith LF, Vernon SA. Trabeculectomy in diabetic patients with glaucoma. Eye (Lond) 1993; 7: 502-506
• 36 Schlenker MB, Gulamhusein H, Conrad-Hengerer I. et al. Efficacy, Safety, and Risk Factors for Failure of Standalone Ab Interno Gelatin Microstent Implantation versus Standalone Trabeculectomy. Ophthalmology 2017; 124: 1579-1588
• 37 Denk PO, Hoppe J, Hoppe V. et al. Effect of growth factors on the activation of human Tenonʼs capsule fibroblasts. Curr Eye Res 2003; 27: 35-44
• 38 Browning AC, Alibhai A, McIntosh RS. et al. Effect of diabetes mellitus and hyperglycemia on the proliferation of human Tenonʼs capsule fibroblasts: Implications for wound healing after glaucoma drainage surgery. Wound Repair Regen 2005; 13: 295-302
• 39 Saarni SI, Härkänen T, Sintonen H. et al. The impact of 29 chronic conditions on health-related quality of life: a general population survey in Finland using 15D and EQ-5D. Qual Life Res 2006; 15: 1403-1414
• 40 Ko Y, Coons SJ. Self-reported chronic conditions and EQ-5D index scores in the US adult population. Curr Med Res Opin 2006; 22: 2065-2071
• 41 Mills T, Law SK, Walt J. et al. Quality of life in glaucoma and three other chronic diseases: a systematic literature review. Drugs Aging 2009; 26: 933-950
• 42 Groff ML, Choi B, Lin T. et al. Anxiety, depression, and sleep-related outcomes of glaucoma patients: systematic review and meta-analysis. Can J Ophthalmol 2022;
• 43 Zheng Y, Wu X, Lin X. et al. The Prevalence of Depression and Depressive Symptoms among Eye Disease Patients: A Systematic Review and Meta-analysis. Sci Rep 2017; 7: 46453
• 44 Azmiardi A, Murti B, Febrinasari RP. et al. Low Social Support and Risk for Depression in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. J Prev Med Public Health 2022; 55: 37-48