Was haben wir aus der deutschen COPD-Kohorte COSYCONET gelernt und wie geht es weiter?

Kathrin Kahnert; Carolina Fischer; Peter Alter; Franziska Trudzinski; Tobias Welte; Jürgen Behr; Felix Herth; Hans-Ulrich Kauczor; Robert Bals; Henrik Watz; Klaus Rabe; Sandra Söhler; Inge Kokot; Claus Vogelmeier; Rudolf Jörres

doi:10.1055/a-1966-0848

Pneumologie, Table of Contents

CC BY-NC-ND 4.0 · Pneumologie 2023; 77(02): 81-93
DOI: 10.1055/a-1966-0848

Übersicht

Was haben wir aus der deutschen COPD-Kohorte COSYCONET gelernt und wie geht es weiter?

What have we learned from the German COPD cohort COSYCONET and where do we go from here?

Kathrin Kahnert

¹Medizinische Klinik und Poliklinik V, Klinikum der Universitat München LMU, Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), München, Deutschland (Ringgold ID: RIN27192)

,

Carolina Fischer

²Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Ludwig-Maximilians-Universität München, München, Deutschland (Ringgold ID: RIN27192)

,

Peter Alter

³Klinik für Pneumologie, Philipps-Universitat Marburg, Member of the German Center for Lung Research (DZL), Marburg, Deutschland (Ringgold ID: RIN9377)

,

Franziska Trudzinski

⁴Thoraxklinik-Heidelberg gGmbH, Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research, Heidelberg, Deutschland (Ringgold ID: RIN14996)

,

Tobias Welte

⁵Klinik für Pneumologie, Medizinische Hochschule Hannover, Member of the German Center of Lung Research (DZL), Hannover, Deutschland (Ringgold ID: RIN9177)

,

Jürgen Behr

¹Medizinische Klinik und Poliklinik V, Klinikum der Universitat München LMU, Comprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), München, Deutschland (Ringgold ID: RIN27192)

,

Felix Herth

⁴Thoraxklinik-Heidelberg gGmbH, Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research, Heidelberg, Deutschland (Ringgold ID: RIN14996)

,

Hans-Ulrich Kauczor

⁶Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research, Heidelberg, Deutschland (Ringgold ID: RIN27178)

,

Robert Bals

⁷Innere Medizin V – Pulmonologie, Allergologie, Beatmungs-und Umweltmedizin, Universitätsklinikum des Saarlandes, Associated member of the Germen Center of Lung Research (DZL), Homburg, Deutschland (Ringgold ID: RIN39072)

⁸Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Deutschland (Ringgold ID: RIN9377)

,

Henrik Watz

⁹Pulmonary Research Institute, LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Deutschland (Ringgold ID: RIN9213)

,

Klaus Rabe

⁹Pulmonary Research Institute, LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Deutschland (Ringgold ID: RIN9213)

¹⁰Medizinische Fakultät, Christian-Albrechts Universität zu Kiel, Kiel, Deutschland (Ringgold ID: RIN98594)

,

Sandra Söhler

³Klinik für Pneumologie, Philipps-Universitat Marburg, Member of the German Center for Lung Research (DZL), Marburg, Deutschland (Ringgold ID: RIN9377)

,

Inge Kokot

³Klinik für Pneumologie, Philipps-Universitat Marburg, Member of the German Center for Lung Research (DZL), Marburg, Deutschland (Ringgold ID: RIN9377)

,

Claus Vogelmeier

³Klinik für Pneumologie, Philipps-Universitat Marburg, Member of the German Center for Lung Research (DZL), Marburg, Deutschland (Ringgold ID: RIN9377)

,

Rudolf Jörres

²Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Ludwig-Maximilians-Universität München, München, Deutschland (Ringgold ID: RIN27192)

› Author Affiliations

Abstract

Zusammenfassung

COSYCONET 1 ist die derzeit einzige international konkurrenzfähige deutsche COPD-Kohorte. Die Rekrutierung begann Ende 2010 und endete im Dezember 2013. Sie resultierte in 2741 Patienten mit der Diagnose einer COPD, die in der Folge in regelmäßigen Visiten nachuntersucht wurden. Diese Visiten umfassten eine umfangreiche funktionelle und klinische Charakterisierung. Auf der Basis dieses hochwertigen Datensatzes war es möglich, eine Vielzahl klinischer Fragen zu beantworten. Diese reichten vom Verschreibungsverhalten über die genaue Analyse verschiedener Komorbiditäten, v.a. kardiovaskulärer Art, bis zu Biomarkern, radiologischen und gesundheitsökonomischen Analysen. Inzwischen wurden mehr als 60 Publikationen zu COSYCONET international veröffentlicht. Die nachstehende Arbeit liefert eine Übersicht über alle bislang erhaltenen Ergebnisse, mit einem besonderen Fokus darauf, deren wechselseitigen Zusammenhang sowie die möglichen praktischen Konsequenzen herauszuarbeiten. Ferner werden einige Informationen über die Folgestudie COSYCONET 2 gegeben.

Abstract

COSYCONET 1 is the only German COPD cohort which is large enough to be internationally comparable. The recruitment, which started in 2010 and ended in December 2013, comprised 2741 patients with the diagnosis of COPD who were subsequently investigated in regular follow-up visits. All visits included a comprehensive functional and clinical characterisation. On the basis of this detailed data set, it was possible to address a large number of clinical questions. These questions ranged from the prescription of medication, the detailed analysis of comorbidities, in particular cardiovascular disease, and biomarker assessment to radiological and health-economic aspects. Currently, more than 60 publications of COSYCONET data are internationally available. The present overview provides a description of all the results that were obtained, focussing on the relationship between different clinical and functional aspects as well as their potential practical consequences. In addition, information on the follow-up study COSYCONET 2 is given.

Schlüsselwörter

COPD - Komorbiditäten - Lungenfunktion - COPD-Therapie

Keywords

COPD - comorbidities - lung function - copd treatment

Full Text

References

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