Multimodaler Ansatz zum Verständnis des Zusammenspiels zwischen dem endokrinen und dem Endocannabinoidsystem, nicht suizidalem selbstverletzendem Verhalten und der Borderline-Persönlichkeitsstörung

ZUSAMMENFASSUNG

Die Borderline-Persönlichkeitsstörung (BPS) und, unabhängig davon, nicht suizidales selbstverletzendes Verhalten (NSSV) sind äußerst prävalente psychiatrische Störungsbilder, welche häufig mit weiteren psychischen Komorbiditäten einhergehen. Dennoch gibt es wenige wissenschaftliche Untersuchungen zu den zugrunde liegenden Mechanismen, die zudem der Verbesserung derzeitiger Behandlungsmöglichkeiten dienen können. Da Cannabiskonsum häufig zur Selbstmedikation bei Patienten mit BPS und NSSV eingesetzt wird und Cannabismissbrauch vermehrt vorkommt, liegt die Untersuchung des Endocannabinoidsystems (ECS) als potenziellen Modulator der Psychopathologie nahe. Des Weiteren sind die Stressverarbeitung als zugrunde liegender Faktor und die Funktionsfähigkeit des endokrinologischen Systems, welches eine zentrale Rolle in der Entwicklung und Aufrechterhaltung der BPS und NSSV spielt, eng mit dem ECS verbunden, welches unter anderem für die Modulation der Hypothalamus-Hypophysen-Nebennierenrinden (HPA)-Achse bekannt ist. Auch wenn mehr Forschung nötig ist, hat das ECS großes Potenzial die Behandlungsmöglichkeiten zu erweitern.

ABSTRACT

Borderline personality disorder (BPD) and independently non-suicidal self-injury (NSSI) are highly prevalent in psychiatric care and often linked to other mental disorders. However, research investigating the underlying neurobiological mechanisms, which could also be beneficial in the enhancement of current treatment options, remains scarce. Since cannabis use as a self-medication and cannabis use disorders are common in patients with BPD and NSSI, investigating the mechanisms of the endocannabinoid system (ECS) as a potential modulator of psychopathology seems plausible. Further, the processing of stress as an underlying factor and the functioning of the endocrinological system, which plays a central role in the development and manifestation of BPD and NSSI, are closely linked to the ECS, which is well known to modulate the hypothalamic-pituitary-adrenal axis (HPA)-axis. Even though more research is needed, the ECS might offer great potential to stimulate and expand current treatment options.

Schlüsselwörter

Endocannabinoidsystem - Borderline-Persönlichkeitsstörung - Immunsystem - nicht suizidal selbstverletzendes Verhalten

Key words

Endocannabinoid system - borderline personality disorder - immune system - non-suicidal self-injurious

Publikationsverlauf

Artikel online veröffentlicht:
03. März 2023

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