Zentralbl Chir 2023; 148(S 01): S51-S70
DOI: 10.1055/a-1990-4810
CME - Fortbildung

Chirurgische oder bronchoskopische Lungenvolumenreduktion zur Emphysemtherapie

Surgical or bronchoscopic lung volume reduction for emphysema therapy
Claudio Caviezel
,
Caroline Steinack
,
Didier Schneiter
,
Thomas Gaisl
,
Isabelle Schmitt-Opitz

Bereits vor über 20 Jahren hat sich die chirurgische Lungenvolumenreduktion (LVRS) bei Patienten mit fortgeschrittenem Lungenemphysem als palliative Therapieoption etabliert, die die Atemnot verringert und die Lungenfunktion und Lebensqualität verbessert. Seit gut 10 Jahren existieren darüber hinaus bronchoskopische Verfahren (BLVR) mit dem Ziel einer Volumenreduktion. Die Vor- und Nachteile von LVRS und BLVR werden in diesem Beitrag diskutiert.

Abstract

More than 20 years ago, surgical lung volume reduction (LVRS) was already established in patients with advanced emphysema as a palliative therapy option that reduces respiratory distress and improves lung function and quality of life. In addition, bronchoscopic procedures (BLVR) aimed at volume reduction have existed for just over 10 years. The advantages and disadvantages of LVRS and BLVR are discussed in this article.

Kernaussagen
  • Die LVRS bietet geeigneten Patienten mit COPD und schwerem Emphysem eine deutliche Verbesserung der Atemnot, Lungenfunktion und Lebensqualität.

  • Die BLVR zeigt bis jetzt nicht nur funktionell gute Ergebnisse, sondern kann auch eine Therapieoption bei Patienten sein, die chirurgisch aufgrund mangelnder Operabilität nicht mehr behandelt werden können.

  • Essenziell ist die interdisziplinäre Beurteilung des Patienten an erfahrenen Zentren.

  • Die Patientenselektion und das Abschätzen des Resektionsausmaßes bleiben Herausforderungen.

  • Die BLVR ist nicht als Konkurrenz zur LVRS, sondern als Ergänzung in der multidisziplinären Behandlung des Emphysempatienten einzuschätzen.



Publication History

Article published online:
21 August 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Fishman A, Martinez F, Naunheim K. et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 2003; 348: 2059-2073
  • 2 Caviezel C, Franzen D, Inci I. et al. [Lung Volume Reduction Surgery – State of the Art 2016]. Zentralbl Chir 2016; 141 (Suppl. 01) S26-S34
  • 3 Slebos DJ, Shah PL, Herth FJ. et al. Endobronchial Valves for Endoscopic Lung Volume Reduction: Best Practice Recommendations from Expert Panel on Endoscopic Lung Volume Reduction. Respiration 2017; 93: 138-150
  • 4 Slebos DJ, Hartman JE, Klooster K. et al. Bronchoscopic Coil Treatment for Patients with Severe Emphysema: A Meta-Analysis. Respiration 2015; 90: 136-145
  • 5 Cassart M, Hamacher J, Verbandt Y. et al. Effects of lung volume reduction surgery for emphysema on diaphragm dimensions and configuration. Am J Respir Crit Care Med 2001; 163: 1171-1175
  • 6 Criner GJ, Cordova F, Sternberg AL. et al. The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery. Am J Respir Crit Care Med 2011; 184: 881-893
  • 7 Gompelmann D, Shah PL, Valipour A. et al. Bronchoscopic Thermal Vapor Ablation: Best Practice Recommendations from an Expert Panel on Endoscopic Lung Volume Reduction. Respiration 2018; 95: 392-400
  • 8 Buttery SC, Banya W, Bilancia R. et al. CELEB investigators. Lung volume reduction surgery versus endobronchial valves: a randomised controlled trial. Eur Respir J 2023; 61: 2202063
  • 9 Rathinam S, Oey I, Steiner M. et al. The role of the emphysema multidisciplinary team in a successful lung volume reduction surgery programme. Eur J Cardiothorac Surg 2014; 46: 1021-1026
  • 10 Inci I, Iskender I, Ehrsam J. et al. Previous lung volume reduction surgery does not negatively affect survival after lung transplantation. Eur J Cardiothorac Surg 2018; 53: 596-602
  • 11 Oey I, Waller D. The role of the multidisciplinary emphysema team meeting in the provision of lung volume reduction. J Thorac Dis 2018; 10 (Suppl. 23) S2824-S2829
  • 12 van Dijk M, Sue R, Criner GJ. et al. Expert Statement: Pneumothorax Associated with One-Way Valve Therapy for Emphysema: 2020 Update. Respiration 2021; 100: 969-978
  • 13 Fishman A, Fessler H, Martinez F. National Emphysema Treatment Trial Research Group. et al. Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med 2001; 345: 1075-1083
  • 14 Caviezel C, Schaffter N, Schneiter D. et al. Outcome After Lung Volume Reduction Surgery in Patients With Severely Impaired Diffusion Capacity. Ann Thorac Surg 2018; 105: 379-385
  • 15 Ciccone AM, Meyers BF, Guthrie TJ. et al. Long-term outcome of bilateral lung volume reduction in 250 consecutive patients with emphysema. J Thorac Cardiovasc Surg 2003; 125: 513-525
  • 16 Hamacher J, Bloch KE, Stammberger U. et al. Two years' outcome of lung volume reduction surgery in different morphologic emphysema types. Ann Thorac Surg 1999; 68: 1792-1798
  • 17 Perikleous P, Sharkey A, Oey I. et al. Long-term survival and symptomatic relief in lower lobe lung volume reduction surgery. Eur J Cardiothorac Surg 2017; 52: 982-988
  • 18 de Torres JP, Bastarrika G, Wisnivesky JP. et al. Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest 2007; 132: 1932-1938
  • 19 Celli BR, Wedzicha JA. Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease. N Engl J Med 2019; 381: 1257-1266
  • 20 Sargent T, Kolderman N, Nair GB. et al. Risk Factors for Pneumothorax Development Following CT-Guided Core Lung Nodule Biopsy. J Bronchology Interv Pulmonol 2022; 29: 198-205
  • 21 Caviezel C, von Rotz J, Schneiter D. et al. Improved postoperative lung function after sublobar resection of non-small-cell lung cancer combined with lung volume reduction surgery in patients with advanced emphysema. J Thorac Dis 2018; 10 (Suppl. 23) S2704-S2710
  • 22 Hiller A, Schneiter D, Opitz I. et al. [Lung Cancer Surgery for Severe COPD with Emphysema: Tumor Resection with Improvement of Lung Function]. Praxis (Bern 1994) 2022; 111: 457-462
  • 23 Wex P, Ebner H, Dragojevic D. Functional surgery of bullous emphysema. Thorac Cardiovasc Surg 1983; 31: 346-351
  • 24 Shen KR, Cerfolio RJ. Decision making in the management of secondary spontaneous pneumothorax in patients with severe emphysema. Thorac Surg Clin 2009; 19: 233-238
  • 25 Caviezel C, Guglielmetti LC, Ladan M. et al. Lung volume reduction surgery as salvage procedure after previous use of endobronchial valves. Interact Cardiovasc Thorac Surg 2021; 32: 263-269
  • 26 Eichhorn ME, Gompelmann D, Hoffmann H. et al. Consolidating Lung Volume Reduction Surgery After Endoscopic Lung Volume Reduction Failure. Ann Thorac Surg 2021; 111: 1858-1865
  • 27 Guibert N, Fumat R, Dupuis M. et al. Bilateral endobronchial valves treatment for severe emphysema. ERJ Open Res 2022; 8: 00672-2021
  • 28 Valipour A, Slebos DJ, Herth F. et al. Endobronchial valve therapy in patients with homogeneous emphysema. Results from the IMPACT study. Am J Respir Crit Care Med 2016; 194: 1073-1082
  • 29 Bloch KE, Georgescu CL, Russi EW. et al. Gain and subsequent loss of lung function after lung volume reduction surgery in cases of severe emphysema with different morphologic patterns. J Thorac Cardiovasc Surg 2002; 123: 845-854
  • 30 Herth FJ, Noppen M, Valipour A. International VENT Study Group. et al. Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort. Eur Respir J 2012; 39: 1334-1342
  • 31 Davey C, Zoumot Z, Jordan S. et al. Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi study): a randomised controlled trial. Lancet 2015; 386: 1066-1073
  • 32 Klooster K, ten Hacken NHT, Hartman JE. et al. Endobronchial valves for emphysema without interlobar collateral ventilation. N Engl J Med 2015; 373: 2325-2335
  • 33 Kemp SV, Slebos DJ, Kirk A. et al. A multicenter RCT of Zephyr endobronchial valve treatment in heterogeneous emphysema (TRANSFORM). Am J Respir Crit Care Med 2017; 196: 1535-1543
  • 34 Criner GJ, Sue R, Wright S. et al. A multicenter RCT of Zephyr endobronchial valve treatment in heterogeneous emphysema (LIBERATE). Am J Respir Crit Care Med 2018; 198: 1151-1164
  • 35 van Geffen WH, Slebos DJ, Herth FJ. et al. Surgical and endoscopic interventions that reduce lung volume for emphysema: a systemic review and meta-analysis. Lancet Respir Med 2019; 7: 313-324
  • 36 Sciurba FC, Ernst A, Herth FJ. et al. A randomized study of endobronchial valves for advanced emphysema. N Engl J Med 2010; 363: 1233-1244
  • 37 Dooms C, Blondeel A, Ceulemans LJ. et al. Lung volume reduction in emphysema: a pragmatic prospective cohort study. ERJ Open Res 2021; 7: 00877-2020
  • 38 Kostron A, Horn-Tutic M, Franzen D. et al. Repeated lung volume reduction surgery is successful in selected patients. Eur J Cardiothorac Surg 2015; 48: 710-715
  • 39 Ing AJ, Jayapadman A, Kim WV. et al. Reversal of collateral ventilation using endoscopic polymer foam in COPD patients undergoing endoscopic lung volume reduction with endobronchial valves: A controlled parallel group trial. Respirology 2022; 27: 1064-1072
  • 40 Lenga P, Grah C, Ruwwe-Glösenkamp C. et al. Endoscopic Lung Volume Reduction with One-Way Valves in Patients with Severe Chronic Obstructive Pulmonary Disease with Hypercapnia. Lung Emphysema Registry Study Group. Respiration 2022; 101: 823-832