Control over Stereogenic N–N Axes by Pd-Catalyzed 5-endo-Hydroaminocyclizations

Dedicated to Prof. Cristina Nevado, recipient of the 2021 Dr. Margaret Faul Women in Chemistry Award

Abstract

A novel approach for the stereoselective construction of N–N atropisomeric compounds by a Pd-catalyzed 5-endo-hydroaminocyclization is described herein. A broad range of bisheterocycles , connected by a configurationally stable N–N stereogenic axis, were prepared with catalyst control in enantioenriched form.

Key words

palladium - cyclization - heterocycles - asymmetric catalysis - alkynes - atropisomers

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