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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(04): 446-452
DOI: 10.1055/a-1996-2980
GebFra Science
Original Article/Originalarbeit

Sonographic Monitoring of Growth of Uterine Myomas in Untreated Women and Respective Influence Factors

Article in several languages: English | deutsch
Vera Seidel
1   Obstetrics, Charité – Universitätsmedizin Berlin, Berlin, Germany
2   Klinik für Gynäkologie, Charité Campus Virchow-Klinikum, Berlin, Germany
,
Klaus Dieter Wernecke
3   Institut für Biometrie und Klinische Epidemiologie, Charité Universitätsmedizin Berlin, Berlin, Germany
4   SOSTANA GmbH, Berlin, Germany
,
Antonia Lukrezia Bellingkrodt
2   Klinik für Gynäkologie, Charité Campus Virchow-Klinikum, Berlin, Germany
,
Robert Armbrust
2   Klinik für Gynäkologie, Charité Campus Virchow-Klinikum, Berlin, Germany
,
Matthias David
2   Klinik für Gynäkologie, Charité Campus Virchow-Klinikum, Berlin, Germany
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Abstract

Research Question What are the growth patterns of uterine myomas in untreated premenopausal women? Which factors influence the growth rate of uterine myomas in premenopausal women?

Method All premenopausal women who presented to the outpatient myoma consultation clinic between January 2005 and March 2022 at least twice were screened. Exclusion criteria were hormonal therapy, pregnancy, and postmenopausal status.

Results A total of 189 patients were included in our study which focused on the respective largest uterine myoma of each woman. An ideal linear growth over time was assumed. Most myomas (82%) increased in size. The mean annual growth of these myomas was 68.42 cm3. The most important prognostic factor for growth was the initial size of the myoma. The absolute annual growth of myomas measuring > 50 cm3 at first presentation was higher compared to smaller myomas (p < 0.001). The relative annual growth rate was highest for myomas measuring between 20 and 50 cm3 at the initial presentation (p = 0.003). The relative annual growth rate in women older than 40 years was significantly lower than that in women below the age of 40 years (p = 0.003).

Conclusion Overall, it is difficult to make an individual prognosis about the growth pattern of a uterine myoma in a specific patient. It should be noted especially in asymptomatic patients that spontaneous regression of myoma size can also occur in premenopausal women.

Key words

myoma - fibroid - myoma growth - ultrasound - premenopause - uterus


Publication History

Received: 09 September 2022

Accepted after revision: 01 December 2022

Article published online:
05 April 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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