Rh(III)-Catalyzed Stereoselective C–H Homoallylation of Indolines with 4-Vinyl-1,3-dioxan-2-ones

Abstract

An efficient and robust Rh(III)-catalyzed C–H homoallylation of indolines has been developed. Using 4-vinyl-1,3-dioxan-2-one as coupling partner, a range of homoallylic alcohols were prepared in excellent stereoselectivities. The current strategy features high efficiency, good yields, and exceptional functional group tolerance.

Key words

C–H homoallylation - Rh(III) catalysis - 4-vinyl-1,3-dioxan-2-ones - indoline - stereoselectivity

Publication History

Received: 18 November 2022

Accepted after revision: 21 December 2022

Accepted Manuscript online:
21 December 2022

Article published online:
16 January 2023

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