Abstract
This review details the isolation, biosynthesis, biological activity, and synthesis of α-hydroxy ketone (acyloin) natural products. The role of these compounds as biosynthetic precursors to complex natural products and synthetic strategies to access the sensitive acyloin moiety and stereochemistry are highlighted.
1 Introduction
1.1 Xenocyloins
1.2 Biological Activity
1.3 Biosynthesis
1.4 Acyloins as Discoipyrrole Biosynthetic Precursors
2 Total Synthesis of Acyloin Natural Products
2.1 Kurasoins A and B
2.2 Soraphinol A and Circumcin B
2.3 4-Hydroxysattabacin and Actinopolymorphol A
2.4 Actinopolymorphol B
2.5 Sattazolins and Sattabacins
2.6 Catalyst Development and Application in Acyloin Synthesis
2.7 Xenocyloins
3 Conclusion
Key words
acyloin - natural products - total synthesis - biosynthesis - biological activity
