Abstract
Glycemic disorder may affect the outcomes of patients with intracerebral
hemorrhage (ICH). However, the association between glycemic variability (GV) and
prognosis in these patients remains to be determined. We performed a
meta-analysis to compressive the influence of GV on functional outcome and
mortality in patients with ICH. Observational studies comparing the risks of
poor functional outcome (defined as modified Rankin Scale>2) and
all-cause mortality between ICH patients with higher versus lower acute GV were
retrieved by systematic search of Medline, Web of Science, Embase, CNKI, and
Wanfang databases. A random-effect model was used to pool the data after
incorporating the between-study heterogeneity. Sensitivity analyses were
performed to evaluate the stability of the findings. Eight cohort studies
involving 3400 patients with ICH were included in the meta-analysis. The
follow-up duration was within 3 months after admission. All of the included
studies used standard deviation of blood glucose (SDBG) as the indicator of
acute GV. Pooled results showed that ICH patients with higher SDBG were
associated with a higher risk of poor functional outcome as compared to those
with lower SDBG [risk ratio (RR): 1.84, 95% confidence interval (CI):
1.41 to 2.42, p<0.001, I2=0%]. In addition, patients
with higher category of SDBG were also associated with a higher mortality risk
(RR: 2.39, 95% CI: 1.79 to 3.19, p<0.001,
I2=0%). In conclusion, high acute GV may be a predictor of poor
functional outcome and mortality of patients with ICH.
Key words
intracerebral hemorrhage - glycemic variability - mortality - functional outcome -
meta-analysis
