Update Breast Cancer 2022 Part 5 – Early Stage Breast Cancer

Tanja N. Fehm; Manfred Welslau; Volkmar Müller; Diana Lüftner; Florian Schütz; Peter A. Fasching; Wolfgang Janni; Christoph Thomssen; Isabell Witzel; Milena Beierlein; Erik Belleville; Michael Untch; Marc Thill; Hans Tesch; Nina Ditsch; Michael P. Lux; Bahriye Aktas; Maggie Banys-Paluchowski; Cornelia Kolberg-Liedtke; Andreas D. Hartkopf; Achim Wöckel; Hans-Christian Kolberg; Nadia Harbeck; Elmar Stickeler

doi:10.1055/a-2018-9053

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(03): 289-298
DOI: 10.1055/a-2018-9053

GebFra Science

Review

Update Mammakarzinom 2022 Teil 5 – Brustkrebs in frühen Krankheitsstadien

Article in several languages: English | deutsch

Tanja N. Fehm

¹Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Manfred Welslau

²Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Volkmar Müller

³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Diana Lüftner

⁴Immanuel Hospital Märkische Schweiz, Buckow; Medical University of Brandenburg Theodor-Fontane, Brandenburg, Germany

,

Florian Schütz

⁵Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Peter A. Fasching

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁷Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Christoph Thomssen

⁸Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Isabell Witzel

³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Milena Beierlein

⁶Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Erik Belleville

⁹ClinSol GmbH & Co. KG, Würzburg, Germany

,

Michael Untch

¹⁰Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Marc Thill

¹¹Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt, Germany

,

Hans Tesch

¹²Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

,

Nina Ditsch

¹³Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Michael P. Lux

¹⁴Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany

,

Bahriye Aktas

¹⁵Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany

,

Maggie Banys-Paluchowski

¹⁶Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

,

Cornelia Kolberg-Liedtke

¹⁷Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

,

Andreas D. Hartkopf

⁷Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Achim Wöckel

¹⁸Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Hans-Christian Kolberg

¹⁹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Nadia Harbeck

²⁰Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Elmar Stickeler

²¹Department of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany

› Author Affiliations

Abstract

Zusammenfassung

Die Behandlung von Patientinnen mit Mammakarzinom in frühen Krankheitsstadien hat sich in den letzten Jahren durch die Einführung von Pembrolizumab, Olaparib und Abemaciclib verändert. Diese und weitere Substanzen dieser Wirkstoffklassen werden derzeit in verschiedenen Indikationen getestet. Diese Übersichtsarbeit fasst die neuesten Ergebnisse zusammen, die entweder auf den großen Kongressen wie dem ESMO 2022 oder kürzlich in internationalen Fachzeitschriften veröffentlicht worden sind. Es wird berichtet von neu entdeckten Brustkrebsgenen, Atezolizumab in der Neoadjuvanz bei HER2-positiven Patientinnen, Langzeitdaten aus der Aphinity-Studie und vom Effekt von Lokalanästhetika, die präoperativ peritumoral appliziert wurden, auf die Prognose. Ebenso werden solide Daten zum dynamischen Ki-67 aus den ADAPT-Studien vorgestellt.

Schlüsselwörter

Brustkrebs - Chirurgie - Chemotherapie - Therapiestandard

Full Text

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