CC BY 4.0 · SynOpen 2023; 07(01): 58-64
DOI: 10.1055/a-2022-3227
paper

Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives

Trisha Mitra
a   University of Kalyani, Kalyani, Nadia, West Bengal 741235, India
,
Soumen Joardar
a   University of Kalyani, Kalyani, Nadia, West Bengal 741235, India
,
b   Mathabhanga College, Mathabhanga, West Bengal 736146, India
,
Manoj Majumdar
b   Mathabhanga College, Mathabhanga, West Bengal 736146, India
,
Mrinalkanti Kundu
c   TCG Lifescience Pvt. Ltd., BN-7, Sector V, Salt Lake City, Kolkata 700091, India
,
Brindaban Roy
a   University of Kalyani, Kalyani, Nadia, West Bengal 741235, India
› Author Affiliations


Abstract

Linearly fused retinoid derivatives have been synthesized via a straightforward pathway using a palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four-step linear approach utilizing iodination, sulfonylation or benzylation or esterification, palladium-catalyzed Sonogashira cross-coupling and palladium-mediated reductive Heck cyclization.

Supporting Information



Publication History

Received: 17 December 2022

Accepted after revision: 30 January 2023

Accepted Manuscript online:
30 January 2023

Article published online:
15 February 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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