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DOI: 10.1055/a-2022-3227
Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives
Abstract
Linearly fused retinoid derivatives have been synthesized via a straightforward pathway using a palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four-step linear approach utilizing iodination, sulfonylation or benzylation or esterification, palladium-catalyzed Sonogashira cross-coupling and palladium-mediated reductive Heck cyclization.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2022-3227.
- Supporting Information
Publication History
Received: 17 December 2022
Accepted after revision: 30 January 2023
Accepted Manuscript online:
30 January 2023
Article published online:
15 February 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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