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Drug Res (Stuttg) 2023; 73(06): 325-334
DOI: 10.1055/a-2024-9964
Original Article

Pluronic F-68 Montmorillonite As A Drug Delivery Vehicle For Extended Release Of Venlafaxine Hydrochloride

Shilpa Jain
1   Department of Chemistry, Shivaji College (University of Delhi), Raja Garden, New Delhi, India.
,
Monika Datta
2   Department of Chemistry, University of Delhi, Delhi, India
› Author Affiliations Funding Information University of Delhi — http://dx.doi.org/10.13039/501100007063; DRCH/R&D/2013–14/4155
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Abstract

Short half-life and low bioavailability of Venlafaxine hydrochloride (VF), an antidepressant drug, necessitates the frequent administration of VF tablets in a day in order to maintain adequate drug concentration in blood plasma. This generates the need for the development of formulations which could prolong the release of VF and reduce the multiple dosages. The present work explores the combination of Montmorillonite (Mt) with Pluronic F-68 (PF-68) (OrganoMT) for oral delivery of VF. The effect of various parameters including pH of aqueous drug solution, contact time and initial drug concentration on drug loading capacity of OrganoMT has been studied. The synthesized OrganoMT-VF complexes were characterized by various suitable techniques. XRD studies indicated that the VF molecules were intercalated within the OrganoMT layers. In vitro release behavior of VF from OrganoMT-VF complexes shows an extended-release pattern for a period of 30 h and reaches upto 70% and 60% compared to pure VF having complete release time of 5.5 h and 3.5 h in simulated gastric and intestinal fluid respectively. Various kinetic models were employed to elucidate the drug release mechanism where the best fitting was obtained with Korsmeyer Peppas model. The results suggest the possibility of designing an oral extended controlled release formulation for VF to minimize its administration frequency thereby increasing the effectiveness of drug. This improves patient compliance by reducing the dose from 4 times in 24 h to once in 24 h.

Key words

Pluronic F-68 - Venlafaxine hydrochloride - Oral extended release - Montmorillonite

Supplementary Material



Publication History

Received: 31 August 2022

Accepted: 26 January 2023

Article published online:
28 April 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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