Gastroenterologie up2date 2024; 20(01): 69-87
DOI: 10.1055/a-2025-3529
Wichtige Methoden in der Gastroenterologie

Transbulbäre und transgastrale Gallengangsdrainage

Indikation, Durchführung, Komplikationen
Philipp Thies
,
Markus Dollhopf

Die endoskopisch retrograde Cholangiopankreatikografie (ERCP) ist der Goldstandard für die Drainage der obstruktiven Cholestase maligner und benigner Erkrankungen, mit einer geringen Misserfolgsrate von 4–16% [1]. Bei fehlgeschlagener ERCP stehen verschiedene endosonografisch geführte Rescue-Verfahren (EUS-BD) zur Verfügung, deren Indikation und Durchführung im Folgenden vorgestellt werden.

Kernaussagen
  • EUS-geführte biliäre Drainagen (EUS-BD) stellen eine Gruppe von „Rescue-Verfahren“ nach fehlgeschlagener ERCP dar.

  • Sie ermöglichen einen direkten Zugang zu den Gallengängen vom Magen oder vom Duodenum aus, ohne dass die Papille zwingend erreicht werden muss.

  • Transduodenal lassen sich der extrahepatische Ductus (hepato-)choledochus und transgastral intrahepatische Gallengänge im linken Leberlappen punktieren.

  • Die Drainagenplatzierung am Zielort erfolgt entweder in Seldinger-Technik (prinzipiell für alle Verfahren realisierbar) oder als Direktpunktionsverfahren bei der EUS-gesteuerten Choledochoduodenostomie und Gallenblasendrainage.

  • Die optimale Drainagestrategie richtet sich nach dem Ort der Obstruktion (distal/hilär) und der zugrunde liegenden Erkrankung (benigne/maligne).

  • Es handelt sich um komplexe Verfahren, bei denen das Ergebnis maßgeblich durch die Fähigkeiten und Erfahrung des Untersuchers und der Expertise des Teams des gesamten Zentrums determiniert wird.

  • Technische und klinische Erfolgsraten von 90% und darüber sind nach Datenlage erreichbar und stellen die Zielvorgabe dar.

  • Je nach Verfahren ist mit Komplikationen in ca. 5–18% der Fälle zu rechnen. Diese sind in der Regel konservativ oder endoskopisch beherrschbar.



Publication History

Article published online:
20 March 2024

© 2024. Thieme. All rights reserved.

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  • Literatur

  • 1 Holt BA, Hawes R, Hasan M. et al. Biliary drainage: role of EUS guidance. Gastrointest Endosc 2016; 83: 160-165
  • 2 Glazer ES, Hornbrook MC, Krouse RS. A meta-analysis of randomized trials: immediate stent placement vs. surgical bypass in the palliative management of malignant biliary obstruction. J Pain Symptom Manage 2014; 47: 307-314
  • 3 Godat S, Bories E, Caillol F. et al. Efficacy and safety in case of technical success of endoscopic ultrasound-guided transhepatic antegrade biliary drainage: A report of a monocentric study. Endosc Ultrasound 2017; 6: 181-186
  • 4 Khashab MA, Valeshabad AK, Afghani E. et al. A comparative evaluation of EUS-guided biliary drainage and percutaneous drainage in patients with distal malignant biliary obstruction and failed ERCP. Dig Dis Sci 2015; 60: 557-565
  • 5 Nam K, Kim DU, Lee TH. et al. Patient perception and preference of EUS-guided drainage over percutaneous drainage when endoscopic transpapillary biliary drainage fails: An international multicenter survey. Endosc Ultrasound 2018; 7: 48-55
  • 6 Sharaiha RZ, Khan MA, Kamal F. et al. Efficacy and safety of EUS-guided biliary drainage in comparison with percutaneous biliary drainage when ERCP fails: a systematic review and meta-analysis. Gastrointest Endosc 2017; 85: 904-914
  • 7 van der Merwe SW, van Wanrooij RLJ, Bronswijk M. et al. Therapeutic endoscopic ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2022; 54: 185-205
  • 8 Veitch AM, Radaelli F, Alikhan R. et al. Endoscopy in patients on antiplatelet or anticoagulant therapy: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guideline update. Endoscopy 2021; 53: 947-969
  • 9 Lange CM, Fichtlscherer S, Miesbach W. et al. The Periprocedural Management of Anticoagulation and Platelet Aggregation Inhibitors in Endoscopic Interventions. Dtsch Arztebl Int 2016; 113: 129-135
  • 10 Chantarojanasiri T, Ratanachu-Ek T, Pausawasdi N. What You Need to Know Before Performing Endoscopic Ultrasound-guided Hepaticogastrostomy. Clin Endosc 2021; 54: 301-308
  • 11 Kamata K, Takenaka M, Minaga K. et al. Stent migration during EUS-guided hepaticogastrostomy in a patient with massive ascites: Troubleshooting using additional EUS-guided antegrade stenting. Arab J Gastroenterol 2017; 18: 120-121
  • 12 Denzer U, Beilenhoff U, Eickhoff A. et al. [S2k guideline: quality requirements for gastrointestinal endoscopy, AWMF registry no. 021–022]. Z Gastroenterol 2015; 53: 1496-1530
  • 13 Johnson G, Webster G, Boškoski I. et al. Curriculum for ERCP and endoscopic ultrasound training in Europe: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy 2021; 53: 1071-1087
  • 14 Jovani M, Ichkhanian Y, Parsa N. et al. Assessment of the learning curve for EUS-guided gastroenterostomy for a single operator. Gastrointest Endosc 2021; 93: 1088-1093
  • 15 Oh D, Park DH, Song TJ. et al. Optimal biliary access point and learning curve for endoscopic ultrasound-guided hepaticogastrostomy with transmural stenting. Therap Adv Gastroenterol 2017; 10: 42-53
  • 16 Tyberg A, Mishra A, Cheung M. et al. Learning curve for EUS-guided biliary drainage: What have we learned?. Endosc Ultrasound 2020; 9: 392-396
  • 17 Krishnamoorthi R, Dasari CS, Thoguluva Chandrasekar V. et al. Effectiveness and safety of EUS-guided choledochoduodenostomy using lumen-apposing metal stents (LAMS): a systematic review and meta-analysis. Surg Endosc 2020; 34: 2866-2877
  • 18 Lu L, Tang X, Jin H. et al. Endoscopic Ultrasound-Guided Biliary Drainage Using Self-Expandable Metal Stent for Malignant Biliary Obstruction. Gastroenterol Res Pract 2017; 2017: 6284094
  • 19 Minaga K, Ogura T, Shiomi H. et al. Comparison of the efficacy and safety of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for malignant distal biliary obstruction: Multicenter, randomized, clinical trial. Dig Endosc 2019; 31: 575-582
  • 20 Itoi T, Binmoeller K, Itokawa F. et al. Endoscopic ultrasonography-guided cholecystogastrostomy using a lumen-apposing metal stent as an alternative to extrahepatic bile duct drainage in pancreatic cancer with duodenal invasion. Dig Endosc 2013; 25 (Suppl. 2) 137-141
  • 21 Will U, Thieme A, Fueldner F. et al. Treatment of biliary obstruction in selected patients by endoscopic ultrasonography (EUS)-guided transluminal biliary drainage. Endoscopy 2007; 39: 292-295
  • 22 Kamal F, Khan MA, Lee-Smith W. et al. Efficacy and safety of EUS-guided gallbladder drainage for rescue treatment of malignant biliary obstruction: A systematic review and meta-analysis. Endosc Ultrasound 2023; 12: 8-15
  • 23 Burmester E, Niehaus J, Leineweber T. et al. EUS-cholangio-drainage of the bile duct: report of 4 cases. Gastrointest Endosc 2003; 57: 246-251
  • 24 van Wanrooij RLJ, Bronswijk M, Kunda R. et al. Therapeutic endoscopic ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review. Endoscopy 2022; 54: 310-332
  • 25 Anderloni A, Fugazza A, Troncone E. et al. Single-stage EUS-guided choledochoduodenostomy using a lumen-apposing metal stent for malignant distal biliary obstruction. Gastrointest Endosc 2019; 89: 69-76
  • 26 Hedjoudje A, Sportes A, Grabar S. et al. Outcomes of endoscopic ultrasound-guided biliary drainage: A systematic review and meta-analysis. United European Gastroenterol J 2019; 7: 60-68
  • 27 Dhindsa BS, Mashiana HS, Dhaliwal A. et al. EUS-guided biliary drainage: A systematic review and meta-analysis. Endosc Ultrasound 2020; 9: 101-109
  • 28 Teoh AYB, Napoleon B, Kunda R. et al. EUS-Guided Choledocho-duodenostomy Using Lumen Apposing Stent Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Biliary Obstruction: A Multicenter Randomized Controlled Trial (DRA-MBO Trial). Gastroenterology 2023; 165: 473-482.e2
  • 29 Chen YI, Sahai A, Donatelli G. et al. Endoscopic Ultrasound-Guided Biliary Drainage of First Intent With a Lumen-Apposing Metal Stent vs Endoscopic Retrograde Cholangiopancreatography in Malignant Distal Biliary Obstruction: A Multicenter Randomized Controlled Study (ELEMENT Trial). Gastroenterology 2023; 165: 1249-1261.e5
  • 30 Imai H, Kitano M, Omoto S. et al. EUS-guided gallbladder drainage for rescue treatment of malignant distal biliary obstruction after unsuccessful ERCP. Gastrointest Endosc 2016; 84: 147-151
  • 31 Chang JI, Dong E, Kwok KK. Endoscopic ultrasound-guided transmural gallbladder drainage in malignant obstruction using a novel lumen-apposing stent: a case series (with video). Endosc Int Open 2019; 7: E655-E661
  • 32 Wang K, Zhu J, Xing L. et al. Assessment of efficacy and safety of EUS-guided biliary drainage: a systematic review. Gastrointest Endosc 2016; 83: 1218-1227
  • 33 Khan MA, Akbar A, Baron TH. et al. Endoscopic Ultrasound-Guided Biliary Drainage: A Systematic Review and Meta-Analysis. Dig Dis Sci 2016; 61: 684-703
  • 34 Paik WH, Lee TH, Park DH. et al. EUS-Guided Biliary Drainage Versus ERCP for the Primary Palliation of Malignant Biliary Obstruction: A Multicenter Randomized Clinical Trial. Am J Gastroenterol 2018; 113: 987-997
  • 35 Kawakami H, Kuwatani M, Kawakubo K. et al. Candy-like sign during endoscopic ultrasound-guided choledochoduodenostomy as an indication of the long distance between the bile duct and duodenal wall. Endoscopy 2014; 46 (Suppl. 1) E406-E407
  • 36 Garcia-Sumalla A, Loras C, Guarner-Argente C. et al. Is a coaxial plastic stent within a lumen-apposing metal stent useful for the management of distal malignant biliary obstruction?. Surg Endosc 2021; 35: 4873-4881
  • 37 Attardo S, Auriemma F, Fugazza A. et al. Rescue management of recurrent duodenal and biliary obstruction due to lumen-apposing metal stent distal migration and duodenal stent ingrowth. Endoscopy 2019; 51: E118-E119